2. Stem Cell/Wnt
  3. Smo
  4. SMO-IN-4

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM). SMO-IN-4 has antitumor activity.

For research use only. We do not sell to patients.

SMO-IN-4 Chemical Structure

SMO-IN-4 Chemical Structure

CAS No. : 1567963-99-8

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SMO-IN-4 Related Antibodies

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Description

SMO-IN-4 (Compound 24) is a potent and orally active smoothened antagonist (IC50: 24 nM). SMO-IN-4 has antitumor activity[1].

In Vitro

SMO-IN-4 (10 μM) shows minimal inhibition of all CYP isoforms, and also has low inhibition on hERG (IC50 = 38 µM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMO-IN-4 Related Antibodies
In Vivo

SMO-IN-4 (50 mg/kg, daily by oral gavage) leads to regression of subcutaneous tumor in a subcutaneous xenograft model of Ptch1+/- mouse medulloblastoma[2].
PK properties of SMO-IN-4 (compound 24)[2].

Species Dose (mg/kg) AUC0-24h (ng·h/mL) Cmax (ng/mL) t1/2 (h) F%
Mouse p.o. (10 mg/kg) 4183 4132 1.0 49
Rat p.o. (10 mg/kg) 5541 2180 2.3 62
Dog p.o. (5 mg/kg) 7656 1300 5.4 72

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

450.96

Formula

C24H27ClN6O
CAS No.
Unlabeled CAS

SMILES

ClC1=CN=C(N2CC3=CN=C(N4CCC(CC4)O)N=C3CC2)C=C1C5=C(C)C=C(C)C=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMO-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-41567963-99-8SmoSmoothenedtumorxenograft modelPtch1medulloblastomaInhibitorinhibitorinhibit

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