Spermidine-d₈ hydrochloride

Name: Spermidine-d 8 hydrochloride
Brand: MedChemExpress
SKU: HY-B1776AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1776AS Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents[1].

For research use only. We do not sell to patients.

Spermidine-d<sub>8</sub> hydrochloride Chemical Structure

Spermidine-d₈ hydrochloride Chemical Structure

CAS No. : 1173019-26-5

Size	Price	Stock	Quantity
1 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of Spermidine-d₈ hydrochloride:

Spermidine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

262.68

Formula

C₇H₁₄D₈Cl₃N₃

CAS No.

1173019-26-5

Unlabeled CAS

334-50-9

Appearance

Solid

Color

White to off-white

SMILES

NCCCNC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N.[H]Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H2O : 250 mg/mL (951.73 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8069 mL	19.0346 mL	38.0691 mL
5 mM	0.7614 mL	3.8069 mL	7.6138 mL
10 mM	0.3807 mL	1.9035 mL	3.8069 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Zhang L, et al. The Alleviation of Heat Damage to Photosystem II and Enzymatic Antioxidants by Exogenous Spermidine in Tall Fescue. Front Plant Sci. 2017 Oct 12;8:1747. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	3.8069 mL	19.0346 mL	38.0691 mL	95.1728 mL
	5 mM	0.7614 mL	3.8069 mL	7.6138 mL	19.0346 mL
	10 mM	0.3807 mL	1.9035 mL	3.8069 mL	9.5173 mL
	15 mM	0.2538 mL	1.2690 mL	2.5379 mL	6.3449 mL
	20 mM	0.1903 mL	0.9517 mL	1.9035 mL	4.7586 mL
	25 mM	0.1523 mL	0.7614 mL	1.5228 mL	3.8069 mL
	30 mM	0.1269 mL	0.6345 mL	1.2690 mL	3.1724 mL
	40 mM	0.0952 mL	0.4759 mL	0.9517 mL	2.3793 mL
	50 mM	0.0761 mL	0.3807 mL	0.7614 mL	1.9035 mL
	60 mM	0.0634 mL	0.3172 mL	0.6345 mL	1.5862 mL
	80 mM	0.0476 mL	0.2379 mL	0.4759 mL	1.1897 mL
	100 mM	0.0381 mL	0.1903 mL	0.3807 mL	0.9517 mL