2. Protein Tyrosine Kinase/RTK
  3. Src
  4. Squarunkin A

Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells.

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Squarunkin A Chemical Structure

Squarunkin A Chemical Structure

CAS No. : 2101958-02-3

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Based on 1 publication(s) in Google Scholar

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Squarunkin A Related Antibodies

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Description

Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1].

IC50 & Target

IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)[1]
In Vitro

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation[1].
Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Squarunkin A Related Antibodies
Molecular Weight

523.55

Formula

C25H32F3N5O4
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC(NC2=C(NCCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)C(C2=O)=O)CC1)OCC
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.62 mg/mL (18.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9100 mL 9.5502 mL 19.1004 mL
5 mM 0.3820 mL 1.9100 mL 3.8201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9100 mL 9.5502 mL 19.1004 mL 47.7509 mL
5 mM 0.3820 mL 1.9100 mL 3.8201 mL 9.5502 mL
10 mM 0.1910 mL 0.9550 mL 1.9100 mL 4.7751 mL
15 mM 0.1273 mL 0.6367 mL 1.2734 mL 3.1834 mL
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Squarunkin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Squarunkin A2101958-02-3SrcUNC119AN-terminalmyristoylatedlipidatedphosphorylationInhibitorinhibitorinhibit

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