Succinic-2,2,3,3-d₄ acid

Name: Succinic-2,2,3,3-d 4 acid
Brand: MedChemExpress
SKU: HY-N0420S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0420S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Succinic-2,2,3,3-d₄ acid is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.

For research use only. We do not sell to patients.

Succinic-2,2,3,3-d<sub>4</sub> acid Chemical Structure

Succinic-2,2,3,3-d₄ acid Chemical Structure

CAS No. : 14493-42-6

Size	Price	Stock	Quantity
50 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Succinic-2,2,3,3-d₄ acid:

Succinic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

122.11

Formula

C₄H₂D₄O₄

CAS No.

14493-42-6

Unlabeled CAS

110-15-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C([2H])([2H])C([2H])([2H])C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (818.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 30 mg/mL (245.68 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.1893 mL	40.9467 mL	81.8934 mL
5 mM	1.6379 mL	8.1893 mL	16.3787 mL
10 mM	0.8189 mL	4.0947 mL	8.1893 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (416 KB)

COA (249 KB) HNMR (96 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O / DMSO	1 mM	8.1893 mL	40.9467 mL	81.8934 mL	204.7334 mL
	5 mM	1.6379 mL	8.1893 mL	16.3787 mL	40.9467 mL
	10 mM	0.8189 mL	4.0947 mL	8.1893 mL	20.4733 mL
	15 mM	0.5460 mL	2.7298 mL	5.4596 mL	13.6489 mL
	20 mM	0.4095 mL	2.0473 mL	4.0947 mL	10.2367 mL
	25 mM	0.3276 mL	1.6379 mL	3.2757 mL	8.1893 mL
	30 mM	0.2730 mL	1.3649 mL	2.7298 mL	6.8244 mL
	40 mM	0.2047 mL	1.0237 mL	2.0473 mL	5.1183 mL
	50 mM	0.1638 mL	0.8189 mL	1.6379 mL	4.0947 mL
	60 mM	0.1365 mL	0.6824 mL	1.3649 mL	3.4122 mL
	80 mM	0.1024 mL	0.5118 mL	1.0237 mL	2.5592 mL
	100 mM	0.0819 mL	0.4095 mL	0.8189 mL	2.0473 mL