Sulbactam-d₅ sodium

Cat. No.: HY-B0334AS Purity: ≥96.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Sulbactam-d₅ (sodium) is the deuterium labeled Sulbactam sodium. Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex[1][2].

For research use only. We do not sell to patients.

Sulbactam-d<sub>5</sub> sodium Chemical Structure

Sulbactam-d₅ sodium Chemical Structure

CAS No. : 1322625-44-4

Size	Price	Stock	Quantity
500 μg	USD 1600	In-stock	Estimated Time of Arrival: December 31

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Other Forms of Sulbactam-d₅ sodium:

Sulbactam sodium In-stock

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

β-lactam

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.25

Formula

C₈H₆D₅NNaO₅S

CAS No.

1322625-44-4

Unlabeled CAS

69388-84-7

Appearance

Solid

Color

White to off-white

SMILES

C(O)(=O)[C@@H]1N2[C@](S(=O)(=O)C1(C([2H])([2H])[2H])C)(C(C2=O)([2H])[2H])[H].[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H2O : ≥ 100 mg/mL (384.25 mM)

DMSO : 50 mg/mL (192.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8425 mL	19.2123 mL	38.4246 mL
5 mM	0.7685 mL	3.8425 mL	7.6849 mL
10 mM	0.3842 mL	1.9212 mL	3.8425 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥96.0%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (255 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Noguchi JK, et al. Sulbactam: a beta-lactamase inhibitor. Clin Pharm. 1988;7(1):37-51. [Content Brief]

[3]. Lin HS, et al. Sulbactam treatment for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex. Infect Dis (Lond). 2015;47(6):370-378. [Content Brief]

[4]. Betrosian AP, et al. Ampicillin-sulbactam: an update on the use of parenteral and oral forms in bacterial infections. Expert Opin Drug Metab Toxicol. 2009;5(9):1099-1112. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H2O	1 mM	3.8425 mL	19.2123 mL	38.4246 mL	96.0615 mL
	5 mM	0.7685 mL	3.8425 mL	7.6849 mL	19.2123 mL
	10 mM	0.3842 mL	1.9212 mL	3.8425 mL	9.6061 mL
	15 mM	0.2562 mL	1.2808 mL	2.5616 mL	6.4041 mL
	20 mM	0.1921 mL	0.9606 mL	1.9212 mL	4.8031 mL
	25 mM	0.1537 mL	0.7685 mL	1.5370 mL	3.8425 mL
	30 mM	0.1281 mL	0.6404 mL	1.2808 mL	3.2020 mL
	40 mM	0.0961 mL	0.4803 mL	0.9606 mL	2.4015 mL
	50 mM	0.0768 mL	0.3842 mL	0.7685 mL	1.9212 mL
	60 mM	0.0640 mL	0.3202 mL	0.6404 mL	1.6010 mL
	80 mM	0.0480 mL	0.2402 mL	0.4803 mL	1.2008 mL
	100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9606 mL