2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. TAK-915

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment.

For research use only. We do not sell to patients.

TAK-915 Chemical Structure

TAK-915 Chemical Structure

CAS No. : 1476727-50-0

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Based on 1 publication(s) in Google Scholar

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Description

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment[1][2].

IC50 & Target[1]

PDE2A

0.61 nM (IC50)

PDE1A

2497 nM (IC50)

In Vivo

TAK-915 (3 mg/kg; oral administration; daily; for 4 days; male F344 rats) treatment significantly reduces escape latency in aged rats in the Morris water maze task[2].
TAK-915 (1, 3, and 10 mg/kg, p.o.) dose-dependently attenuates the non-selective muscarinic antagonist scopolamine-induced memory deficits in rats[2].
Oral dosing of TAK-915 (compound 36) (3 or 10 mg/kg) in mice produces a dose-dependent increase in 3',5'-cyclic guanosine monophosphate (cGMP) levels, with significant cGMP increases observed at a dose of 10 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male F344 rats (10-week-old and 26-month-old) bearing morris water maze task[2]
Dosage: 3 mg/kg
Administration: Oral administration; daily; for 4 days
Result: Significantly reduced escape latency in aged rats in the Morris water maze task.
Clinical Trial
Molecular Weight

458.36

Formula

C19H18F4N4O5
CAS No.
Unlabeled CAS

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1)CN(C(N[C@@H](C2=CC(F)=C(OC(F)(F)F)C=C2)COC)=O)C3=C1C=C(OC)C=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.5 mg/mL (16.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1817 mL 10.9085 mL 21.8169 mL
5 mM 0.4363 mL 2.1817 mL 4.3634 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

COA (249 KB) HNMR (316 KB) RP-HPLC (256 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1817 mL 10.9085 mL 21.8169 mL 54.5423 mL
5 mM 0.4363 mL 2.1817 mL 4.3634 mL 10.9085 mL
10 mM 0.2182 mL 1.0908 mL 2.1817 mL 5.4542 mL
15 mM 0.1454 mL 0.7272 mL 1.4545 mL 3.6362 mL
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TAK-915 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK-9151476727-50-0TAK915TAK 915Phosphodiesterase (PDE)PDE2ABBBcognitivedisordersstabilityoralneuropsychiatriccGMPInhibitorinhibitorinhibit

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