2. Peptides
  3. Tat-NTS peptide

Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Tat-NTS peptide Chemical Structure

Tat-NTS peptide Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Tat-NTS peptide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke[1].

In Vitro

Tat-NTS peptide (20 μM) blocks ANXA1 nuclear migration in neuronal cells without affecting the nuclear translocation of other proteins[1].
Tat-NTS peptide (20 μM) inhibits the binding of ANXA1 to p53, alleviates neuronal apoptosis induced by oxygen glucose deprivation/reperfusion (OGD/R), and has neuronal cytoprotective effects[1].
Tat-NTS peptide (20 μM) can significantly improve the viability of neuronal cells after OGD/R[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tat-NTS peptide Related Antibodies

Western Blot Analysis[1]

Cell Line: neuronal cells
Concentration: 20 μM
Incubation Time:
Result: Significantly decreased the level of ANXA1 protein in the nuclear fraction, and had no impact on the subcellular localization of p65 and β-catenin.
Significantly decreased Bid protein levels.
Significantly decreased OGD/R-triggered tBid expression and caspase-9, PARP, caspase-3 cleavage but had little effect on the activation of caspase-8.

RT-PCR[1]

Cell Line: neuronal cells
Concentration: 20 μM
Incubation Time:
Result: Significantly decreased Bid mRNA levels.
In Vivo

Tat-NTS peptide (0.5-10 mg/kg; nilateral Intracerebroventricular (i.c.v.) Injection; single dose) reduces the interaction between ANXA1 and importin β in C57BL/6 mice with middle cerebral artery occlusion (MCAO) and prevents the nuclear translocation of ANXA1 in vivo. Tat-NTS peptide alleviates neuronal apoptosis after ischemic injury in mice, exhibiting neuroprotective effects against cerebral ischemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCAO C57BL/6 mice model[1]
Dosage: 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg, 10 mg/kg.
Administration: Unilateral Intracerebroventricular (i.c.v.) Injection: Single dose. After undergoing 1-hour middle cerebral artery occlusion (MCAO)
Result: Significantly inhibited the protein level of tBid, cleaved caspase-9, cleaved PARP, and caspase-3, and had little effect on the activation of caspase-8.
Reduced the infarct volume and improved neurological outcomes following focal ischemic injury.
Molecular Weight

2855.37

Formula

C125H212N54O24
Unlabeled Cas

Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
Sequence Shortening

YGRKKRRQRRRRSFPHLRRVF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Tat-NTS peptide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tat-NTS peptideOthersC57BL/6 miceneuronal apoptosisoxygen glucose deprivation/reperfusion (OGD/R)middle cerebral artery occlusion (MCAO)neuroprotectantischemic strokeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tat-NTS peptide
Cat. No.:
HY-P10275
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.