2. GPCR/G Protein Autophagy
  3. Angiotensin Receptor Autophagy
  4. Telmisartan-d3

Telmisartan-d3 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

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Telmisartan-d<sub>3</sub> Chemical Structure

Telmisartan-d3 Chemical Structure

CAS No. : 1189889-44-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Telmisartan-d3:

Telmisartan-d3 Related Antibodies

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Description

Telmisartan-d3 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telmisartan-d3 Related Antibodies
Molecular Weight

517.64

Formula

C33H27D3N4O2
CAS No.
Unlabeled CAS

144701-48-4
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(C2=NC3=C(N2C([2H])([2H])[2H])C=CC=C3)=CC4=C1N=C(N4CC5=CC=C(C=C5)C6=CC=CC=C6C(O)=O)CCC
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 1.6 mg/mL (3.09 mM)

DMSO : ≥ 1 mg/mL (1.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (0.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9318 mL 9.6592 mL 19.3184 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 1.9318 mL 9.6592 mL 19.3184 mL 48.2961 mL
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Telmisartan-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telmisartan-d31189889-44-8Angiotensin ReceptorAutophagyInhibitorinhibitorinhibit

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