2. Metabolic Enzyme/Protease Others
  3. Dihydroorotate Dehydrogenase Isotope-Labeled Compounds
  4. Teriflunomide-d4

Teriflunomide-d4  (Synonyms: A77 1726-d4)

Cat. No.: HY-110159S Purity: 99.98%
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Teriflunomide-d4 is deuterium labeled Teriflunomide.

For research use only. We do not sell to patients.

Teriflunomide-d<sub>4</sub> Chemical Structure

Teriflunomide-d4 Chemical Structure

CAS No. : 1185240-22-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Teriflunomide-d4:

Teriflunomide-d4 Related Antibodies

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Description

Teriflunomide-d4 is deuterium labeled Teriflunomide.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Teriflunomide-d4 Related Antibodies
Clinical Trial
Molecular Weight

274.23

Formula

C12H5D4F3N2O2
CAS No.
Unlabeled CAS

163451-81-8
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=C([2H])C([2H])=C(C([2H])=C1[2H])NC(/C(C#N)=C(O)/C)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (91.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6466 mL 18.2329 mL 36.4657 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6466 mL 18.2329 mL 36.4657 mL 91.1643 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL 18.2329 mL
10 mM 0.3647 mL 1.8233 mL 3.6466 mL 9.1164 mL
15 mM 0.2431 mL 1.2155 mL 2.4310 mL 6.0776 mL
20 mM 0.1823 mL 0.9116 mL 1.8233 mL 4.5582 mL
25 mM 0.1459 mL 0.7293 mL 1.4586 mL 3.6466 mL
30 mM 0.1216 mL 0.6078 mL 1.2155 mL 3.0388 mL
40 mM 0.0912 mL 0.4558 mL 0.9116 mL 2.2791 mL
50 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.8233 mL
60 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5194 mL
80 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1396 mL
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Teriflunomide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teriflunomide-d41185240-22-5A77 1726-d4Dihydroorotate DehydrogenaseIsotope-Labeled CompoundsDHODHInhibitorinhibitorinhibit

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