Thiocolchicine-d₃

Name: Thiocolchicine-d 3
Brand: MedChemExpress
SKU: HY-116852S
Rating: 4.5 (1 reviews)

Cat. No.: HY-116852S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

For research use only. We do not sell to patients.

Thiocolchicine-d<sub>3</sub> Chemical Structure

Thiocolchicine-d₃ Chemical Structure

CAS No. : 1314417-95-2

Size	Price	Stock	Quantity
1 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Thiocolchicine-d₃:

Thiocolchicine In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

418.52

Formula

C₂₂H₂₂D₃NO₅S

CAS No.

1314417-95-2

Unlabeled CAS

2730-71-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (238.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3894 mL	11.9469 mL	23.8937 mL
5 mM	0.4779 mL	2.3894 mL	4.7787 mL
10 mM	0.2389 mL	1.1947 mL	2.3894 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (260 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476

[3]. R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13(1):19-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3894 mL	11.9469 mL	23.8937 mL	59.7343 mL
	5 mM	0.4779 mL	2.3894 mL	4.7787 mL	11.9469 mL
	10 mM	0.2389 mL	1.1947 mL	2.3894 mL	5.9734 mL
	15 mM	0.1593 mL	0.7965 mL	1.5929 mL	3.9823 mL
	20 mM	0.1195 mL	0.5973 mL	1.1947 mL	2.9867 mL
	25 mM	0.0956 mL	0.4779 mL	0.9557 mL	2.3894 mL
	30 mM	0.0796 mL	0.3982 mL	0.7965 mL	1.9911 mL
	40 mM	0.0597 mL	0.2987 mL	0.5973 mL	1.4934 mL
	50 mM	0.0478 mL	0.2389 mL	0.4779 mL	1.1947 mL
	60 mM	0.0398 mL	0.1991 mL	0.3982 mL	0.9956 mL
	80 mM	0.0299 mL	0.1493 mL	0.2987 mL	0.7467 mL
	100 mM	0.0239 mL	0.1195 mL	0.2389 mL	0.5973 mL