2. Apoptosis NF-κB
  3. TNF Receptor NF-κB Apoptosis
  4. TNF-α (31-45), human TFA

TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis.

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TNF-α (31-45), human TFA Chemical Structure

TNF-α (31-45), human TFA Chemical Structure

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TNF-α (31-45), human TFA Related Antibodies

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Description

TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].

IC50 & Target[1][2]

NF-κB

 

In Vitro

TNF-α (31-45), human (5 μM; for 1 h) TFA promotes cisplatin resistance by the activation of the NF-kB pathway. TNF-α (31-45), human does not alter RPS3 expression levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNF-α (31-45), human TFA Related Antibodies
Molecular Weight

1667.87 (free acid)

Formula

C69H122N26O22.xC2HF3O2
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence Shortening

RRANALLANGVELRD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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TNF-α (31-45), human TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α (31-45), humanTNF ReceptorNF-κBApoptosisTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBproinflammatory cytokinenecrosisinvasionmetastasisInhibitorinhibitorinhibit

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TNF-α (31-45), human TFA
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