Tolterodine-d₁₄ hydrochloride (Synonyms: (R)-(+)-Tolterodine-d₁₄ hydrochloride; (+)-Tolterodine-d₁₄ hydrochloride; (R)-Tolterodine-d₁₄ hydrochloride; PNU-200583-d₁₄ hydrochloride)

Name: Tolterodine-d 14 hydrochloride
Brand: MedChemExpress
SKU: HY-A0024S
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0024S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride[1]. Tolterodine hydrochloride is a potent muscarinic receptor antagonist[2][3].

For research use only. We do not sell to patients.

Tolterodine-d<sub>14</sub> hydrochloride Chemical Structure

Tolterodine-d₁₄ hydrochloride Chemical Structure

CAS No. : 1217645-16-3

Size	Price	Stock	Quantity
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
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10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride[1]. Tolterodine hydrochloride is a potent muscarinic receptor antagonist[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.03

Formula

C₂₂H₁₈D₁₄ClNO

CAS No.

1217645-16-3

Unlabeled CAS

124937-51-5

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])N(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])CC[C@H](C1=CC=CC=C1)C2=C(C=CC(C)=C2)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

Ethanol : 120 mg/mL (319.12 mM; Need ultrasonic)

DMSO : 100 mg/mL (265.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6594 mL	13.2968 mL	26.5936 mL
5 mM	0.5319 mL	2.6594 mL	5.3187 mL
10 mM	0.2659 mL	1.3297 mL	2.6594 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (260 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7. [Content Brief]

[3]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35. [Content Brief]

[4]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	2.6594 mL	13.2968 mL	26.5936 mL	66.4841 mL
	5 mM	0.5319 mL	2.6594 mL	5.3187 mL	13.2968 mL
	10 mM	0.2659 mL	1.3297 mL	2.6594 mL	6.6484 mL
	15 mM	0.1773 mL	0.8865 mL	1.7729 mL	4.4323 mL
	20 mM	0.1330 mL	0.6648 mL	1.3297 mL	3.3242 mL
	25 mM	0.1064 mL	0.5319 mL	1.0637 mL	2.6594 mL
	30 mM	0.0886 mL	0.4432 mL	0.8865 mL	2.2161 mL
	40 mM	0.0665 mL	0.3324 mL	0.6648 mL	1.6621 mL
	50 mM	0.0532 mL	0.2659 mL	0.5319 mL	1.3297 mL
	60 mM	0.0443 mL	0.2216 mL	0.4432 mL	1.1081 mL
	80 mM	0.0332 mL	0.1662 mL	0.3324 mL	0.8311 mL
	100 mM	0.0266 mL	0.1330 mL	0.2659 mL	0.6648 mL

Tolterodine-d₁₄ hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolterodine-d₁₄1217645-16-3(R)-(+)-Tolterodine-d₁₄(+)-Tolterodine-d₁₄(R)-Tolterodine-d₁₄PNU-200583-d₁₄mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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Tolterodine-d14 hydrochloride (Synonyms: (R)-(+)-Tolterodine-d14 hydrochloride; (+)-Tolterodine-d14 hydrochloride; (R)-Tolterodine-d14 hydrochloride; PNU-200583-d14 hydrochloride)

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Tolterodine-d14 hydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Tolterodine-d14 hydrochloride Related Classifications

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Tolterodine-d₁₄ hydrochloride (Synonyms: (R)-(+)-Tolterodine-d₁₄ hydrochloride; (+)-Tolterodine-d₁₄ hydrochloride; (R)-Tolterodine-d₁₄ hydrochloride; PNU-200583-d₁₄ hydrochloride)

Other Forms of Tolterodine-d₁₄ hydrochloride:

Tolterodine-d₁₄ hydrochloride Related Antibodies

Tolterodine-d₁₄ hydrochloride Related Antibodies

Tolterodine-d₁₄ hydrochloride Related Classifications