TUG-905

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TUG-905 is a potent GPR40 agonist with an pEC₅₀ value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression.

For research use only. We do not sell to patients.

TUG-905 Chemical Structure

CAS No. : 1390641-90-3

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Description

IC₅₀ & Target

pEC₅₀: 7.03 (GPR40)^[1]

In Vitro

TUG-905 (10 µM; 7, 13 days) increases cell proliferation and DCX mRNA levels of the neuroblast marker^[2].
TUG-905 (10 µM; 2, 4, 24 h) increases GPR40, BDNF gene expression in Neuro2a (murine neuroblastoma) cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	DCX/GFAP positive cells (neurospheres from mouse hypothalamic tissue)
Concentration:	10 µM
Incubation Time:	7 days
Result:	Increased mRNA levels of the neuroblast marker, DCX, as well as the number of DCX-immunopositive cells.

In Vivo

TUG-905 (2.0 μL, 1.0 mM; i.c.v.; twice a day for 6 days) reduces body mass and exhibited a trend toward reducing caloric intake^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6 weeks, Male Swiss mice^[1]
Dosage:	2.0 μL, 1.0 mM
Administration:	I.c.v.; twice a day for 6 days
Result:	Reduced body mass and exhibited a trend toward reducing caloric intake, and induced an increase of IL10 and IL6 in the hypothalamus, and increased the POMC mRNA expression.

Molecular Weight

499.59

Formula

C₂₇H₃₀FNO₅S

CAS No.

1390641-90-3

Unlabeled CAS

SMILES

O=C(CCC1=CC=C(C=C1F)NCC2=CC(C3=CC=C(C=C3C)OCCCS(=O)(C)=O)=CC=C2)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. [Content Brief]

[2]. Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047. [Content Brief]

TUG-905 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TUG-9051390641-90-3TUG905TUG 905Free Fatty Acid ReceptorFFARproliferationhypothalamic cellbody massPOMCDCXInhibitorinhibitorinhibit

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