Uperolein 

Uperolein is a physalaemin-like endecapeptide, produced in the skin of Uperoleia rugosa and Uperoleia marmorata. Uperolein has a spasmodic effect on both the gastrointestinal tract and longitudinal muscles^[1][2][3].

Uperolein (10-100 ng/mL) is a tachykinin analogue, causes or reinforces rhythmic movements and increases the tone in isolated circular and longitudinal muscle of the human gastrointestinal tract from the stomach to the colon^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uperolein (0.1 μg/kg and 5 μg/kg; i.v.; single dose) exhibits stimulation activity on the stomach of the anesthetized rat, displays a noticeable spasmogenic activity on the whole stomach from the fundus to the pylorus^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1234.38

C₅₇H₇₉N₁₃O₁₆S

55601-63-3

{Pyr}-PDPNAFYGLM-NH2

O=C(N(CCC1)[C@@H]1C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC(C=C2)=CC=C2O)=O)CC3=CC=CC=C3)=O)=O)=O)[C@H](CC(O)=O)NC([C@H](CCC4)N4C([C@@H](N5)CCC5=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83.  [Content Brief]

  [2]. Anastasi A, et al. Structure of uperolein, a physalaemin-like endecapeptide occurring in the skin of Uperoleia rugosa and Uperoleia marmorata. Experientia. 1975 Apr 15;31(4):394-5.  [Content Brief]

  [3]. Zappia L, et al. Effects of natural analogues of substance P on the motility of human gastrointestinal tract in vitro. J Pharm Pharmacol. 1978 Sep;30(9):593-4.  [Content Brief]

  [4]. Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6.  [Content Brief]