2. Stem Cell/Wnt
  3. β-catenin Wnt
  4. UU-T02

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells.

For research use only. We do not sell to patients.

UU-T02 Chemical Structure

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

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5 mg USD 600 In-stock
10 mg USD 850 In-stock
25 mg USD 1360 In-stock
50 mg USD 2050 In-stock
100 mg USD 3075 In-stock
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Based on 1 publication(s) in Google Scholar

UU-T02 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE UU-T02

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Description

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].

IC50 & Target

Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].
In Vitro

UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM，respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UU-T02 Related Antibodies
Molecular Weight

665.09

Formula

C33H33ClN4O9
CAS No.
Unlabeled CAS

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(CC[C@@H](C(OC)=O)NC([C@H](CC(O)=O)NC([C@H](CC1=CC2=C(C=CC=C2)C=C1)NC(CC3=CC4=CC(Cl)=CC=C4N3)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (187.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5036 mL 7.5178 mL 15.0356 mL
5 mM 0.3007 mL 1.5036 mL 3.0071 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5036 mL 7.5178 mL 15.0356 mL 37.5889 mL
5 mM 0.3007 mL 1.5036 mL 3.0071 mL 7.5178 mL
10 mM 0.1504 mL 0.7518 mL 1.5036 mL 3.7589 mL
15 mM 0.1002 mL 0.5012 mL 1.0024 mL 2.5059 mL
20 mM 0.0752 mL 0.3759 mL 0.7518 mL 1.8794 mL
25 mM 0.0601 mL 0.3007 mL 0.6014 mL 1.5036 mL
30 mM 0.0501 mL 0.2506 mL 0.5012 mL 1.2530 mL
40 mM 0.0376 mL 0.1879 mL 0.3759 mL 0.9397 mL
50 mM 0.0301 mL 0.1504 mL 0.3007 mL 0.7518 mL
60 mM 0.0251 mL 0.1253 mL 0.2506 mL 0.6265 mL
80 mM 0.0188 mL 0.0940 mL 0.1879 mL 0.4699 mL
100 mM 0.0150 mL 0.0752 mL 0.1504 mL 0.3759 mL
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UU-T02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UU-T021500080-17-0β-cateninWntBeta cateninsignalingcolorectalcancer cellFP assayAlphaScreen assayInhibitorinhibitorinhibit

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