Valproic acid-d₁₅ (Synonyms: VPA-d₁₅; 2-Propylpentanoic Acid-d₁₅)

Name: Valproic acid-d 15
Brand: MedChemExpress
SKU: HY-10585S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-10585S2 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Valproic acid-d₁₅ is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

For research use only. We do not sell to patients.

Valproic acid-d<sub>15</sub> Chemical Structure

Valproic acid-d₁₅ Chemical Structure

CAS No. : 362049-65-8

Size	Price	Stock	Quantity
5 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 108	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Valproic acid-d₁₅:

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

159.30

Formula

C₈HD₁₅O₂

CAS No.

362049-65-8

Unlabeled CAS

99-66-1

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C(C(O)=O)([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (627.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.2775 mL	31.3873 mL	62.7746 mL
5 mM	1.2555 mL	6.2775 mL	12.5549 mL
10 mM	0.6277 mL	3.1387 mL	6.2775 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. [Content Brief]

[3]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [Content Brief]

[4]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [Content Brief]

[5]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [Content Brief]

[6]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [Content Brief]

[7]. Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148(1):31-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.2775 mL	31.3873 mL	62.7746 mL	156.9366 mL
	5 mM	1.2555 mL	6.2775 mL	12.5549 mL	31.3873 mL
	10 mM	0.6277 mL	3.1387 mL	6.2775 mL	15.6937 mL
	15 mM	0.4185 mL	2.0925 mL	4.1850 mL	10.4624 mL
	20 mM	0.3139 mL	1.5694 mL	3.1387 mL	7.8468 mL
	25 mM	0.2511 mL	1.2555 mL	2.5110 mL	6.2775 mL
	30 mM	0.2092 mL	1.0462 mL	2.0925 mL	5.2312 mL
	40 mM	0.1569 mL	0.7847 mL	1.5694 mL	3.9234 mL
	50 mM	0.1255 mL	0.6277 mL	1.2555 mL	3.1387 mL
	60 mM	0.1046 mL	0.5231 mL	1.0462 mL	2.6156 mL
	80 mM	0.0785 mL	0.3923 mL	0.7847 mL	1.9617 mL
	100 mM	0.0628 mL	0.3139 mL	0.6277 mL	1.5694 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valproic acid-d₁₅362049-65-8VPA-d₁₅2-Propylpentanoic Acid-d₁₅HDACAutophagyMitophagyHIVNotchEndogenous MetaboliteHistone deacetylasesMitochondrial AutophagyHuman immunodeficiency virusInhibitorinhibitorinhibit

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Valproic acid-d15 (Synonyms: VPA-d15; 2-Propylpentanoic Acid-d15)

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Valproic acid-d₁₅ (Synonyms: VPA-d₁₅; 2-Propylpentanoic Acid-d₁₅)

Other Forms of Valproic acid-d₁₅:

Valproic acid-d₁₅ Related Antibodies

Valproic acid-d₁₅ Related Antibodies

Valproic acid-d₁₅ Related Classifications