Valsartan-d₈ (Synonyms: CGP 48933-d₈)

Name: Valsartan-d 8
Brand: MedChemExpress
SKU: HY-18204S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-18204S2 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Valsartan-d₈ is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

For research use only. We do not sell to patients.

Valsartan-d<sub>8</sub> Chemical Structure

Valsartan-d₈ Chemical Structure

CAS No. : 1089736-72-0

Size	Price	Stock	Quantity
1 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Valsartan-d₈:

Valsartan In-stock

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Description

Valsartan-d₈ is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

443.57

Formula

C₂₄H₂₁D₈N₅O₃

CAS No.

1089736-72-0

Unlabeled CAS

137862-53-4

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])[C@](C(O)=O)([2H])N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (112.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (2.25 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2544 mL	11.2722 mL	22.5444 mL
5 mM	0.4509 mL	2.2544 mL	4.5089 mL
10 mM	0.2254 mL	1.1272 mL	2.2544 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (260 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80. [Content Brief]

[3]. Wang Y, et al. Valsartan blocked alcohol-induced, Toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40. [Content Brief]

[4]. Sui X, et al. Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction. J Cell Mol Med. 2015 Aug;19(8):1773-82. [Content Brief]

[5]. Jiang Y, et al. Cardioprotective effect of valsartan in mice with short-term high-salt diet by regulating cardiac aquaporin 1 and angiogenic factor expression. Cardiovasc Pathol. 2015 Jul-Aug;24(4):224-9. [Content Brief]

[6]. Ping G, et al. Valsartan reverses depressive/anxiety-like behavior and induces hippocampal neurogenesis and expression of BDNF protein in unpredictable chronic mild stress mice. Pharmacol Biochem Behav. 2014 Sep;124:5-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O / DMSO	1 mM	2.2544 mL	11.2722 mL	22.5444 mL	56.3609 mL
DMSO	5 mM	0.4509 mL	2.2544 mL	4.5089 mL	11.2722 mL
	10 mM	0.2254 mL	1.1272 mL	2.2544 mL	5.6361 mL
	15 mM	0.1503 mL	0.7515 mL	1.5030 mL	3.7574 mL
	20 mM	0.1127 mL	0.5636 mL	1.1272 mL	2.8180 mL
	25 mM	0.0902 mL	0.4509 mL	0.9018 mL	2.2544 mL
	30 mM	0.0751 mL	0.3757 mL	0.7515 mL	1.8787 mL
	40 mM	0.0564 mL	0.2818 mL	0.5636 mL	1.4090 mL
	50 mM	0.0451 mL	0.2254 mL	0.4509 mL	1.1272 mL
	60 mM	0.0376 mL	0.1879 mL	0.3757 mL	0.9393 mL
	80 mM	0.0282 mL	0.1409 mL	0.2818 mL	0.7045 mL
	100 mM	0.0225 mL	0.1127 mL	0.2254 mL	0.5636 mL

Valsartan-d₈ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valsartan-d₈1089736-72-0CGP 48933-d₈Angiotensin ReceptorInhibitorinhibitorinhibit

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Valsartan-d8 (Synonyms: CGP 48933-d8)

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Complete Stock Solution Preparation Table

Valsartan-d8 Related Classifications

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Valsartan-d₈ (Synonyms: CGP 48933-d₈)

Other Forms of Valsartan-d₈:

Valsartan-d₈ Related Antibodies

Valsartan-d₈ Related Antibodies

Valsartan-d₈ Related Classifications