2. PROTAC Metabolic Enzyme/Protease
  3. Ligands for E3 Ligase HIF/HIF Prolyl-Hydroxylase PROTACs
  4. VHL-IN-1

VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. VHL-IN-1 has potential as a HIF-1α stabilizer and degrader of proteolytically targeted chimeras (PROTACs).

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VHL-IN-1 Chemical Structure

VHL-IN-1 Chemical Structure

CAS No. : 3033117-53-9

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5 mg USD 402 In-stock
10 mg USD 644 In-stock
25 mg USD 1289 In-stock
50 mg USD 2062 In-stock
100 mg USD 3300 In-stock
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Based on 1 publication(s) in Google Scholar

VHL-IN-1 Related Antibodies

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Description

VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. VHL-IN-1 has potential as a HIF-1α stabilizer and degrader of proteolytically targeted chimeras (PROTACs)[1].

IC50 & Target

Kd=: 37 nM (von Hippel-Lindau (VHL)); HIF-1α[1]
Molecular Weight

544.68

Formula

C28H37FN4O4S
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C3=CC=C(C4=C(C)N=CS4)C=C3C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (183.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8359 mL 9.1797 mL 18.3594 mL
5 mM 0.3672 mL 1.8359 mL 3.6719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8359 mL 9.1797 mL 18.3594 mL 45.8985 mL
5 mM 0.3672 mL 1.8359 mL 3.6719 mL 9.1797 mL
10 mM 0.1836 mL 0.9180 mL 1.8359 mL 4.5899 mL
15 mM 0.1224 mL 0.6120 mL 1.2240 mL 3.0599 mL
20 mM 0.0918 mL 0.4590 mL 0.9180 mL 2.2949 mL
25 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8359 mL
30 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5300 mL
40 mM 0.0459 mL 0.2295 mL 0.4590 mL 1.1475 mL
50 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
60 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7650 mL
80 mM 0.0229 mL 0.1147 mL 0.2295 mL 0.5737 mL
100 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
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VHL-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VHL-IN-13033117-53-9Ligands for E3 LigaseHIF/HIF Prolyl-HydroxylasePROTACsE3 ligase-recruiting MoietyHypoxia-inducible factorsHIFsHIF-PHvon Hippel-Lindau (VHL)HIF-1Inhibitorinhibitorinhibit

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