2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. WAY-100135 dihydrochloride

WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.

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WAY-100135 dihydrochloride Chemical Structure

WAY-100135 dihydrochloride Chemical Structure

CAS No. : 149055-79-8

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Based on 1 publication(s) in Google Scholar

WAY-100135 dihydrochloride Related Antibodies

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Description

WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties[1][2].

IC50 & Target[1]

5-HT1A Receptor

34 nM (IC50)

In Vitro

WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA2 of 7.2[1].
WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WAY-100135 dihydrochloride Related Antibodies
In Vivo

WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1].
WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

468.46

Formula

C24H35Cl2N3O2
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(C)(C)C)C(C1=CC=CC=C1)CN2CCN(C3=CC=CC=C3OC)CC2.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (10.67 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1347 mL 10.6733 mL 21.3465 mL
5 mM 0.4269 mL 2.1347 mL 4.2693 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1347 mL 10.6733 mL 21.3465 mL 53.3664 mL
5 mM 0.4269 mL 2.1347 mL 4.2693 mL 10.6733 mL
10 mM 0.2135 mL 1.0673 mL 2.1347 mL 5.3366 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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WAY-100135 dihydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-100135149055-79-8WAY100135WAY 1001355-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorpresynapticpostsynapticantipsychoticInhibitorinhibitorinhibit

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