(Z)-10-Hydroxynortriptyline-d₃

Name: (Z)-10-Hydroxynortriptyline-d 3
Brand: MedChemExpress
SKU: HY-100646AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-100646AS Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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(Z)-10-Hydroxynortriptyline-d₃ is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1][2].

For research use only. We do not sell to patients.

(Z)-10-Hydroxynortriptyline-d<sub>3</sub> Chemical Structure

(Z)-10-Hydroxynortriptyline-d₃ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (Z)-10-Hydroxynortriptyline-d₃:

(Z)-10-Hydroxynortriptyline In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.40

Formula

C₁₉H₁₈D₃NO

Unlabeled CAS

47132-19-4

Appearance

Solid

Color

White to light yellow

SMILES

OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C\CCNC([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 30 mg/mL (106.23 mM)

DMSO : ≥ 10 mg/mL (35.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 5 mg/mL (17.71 mM)

DMF:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (1.77 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5411 mL	17.7054 mL	35.4108 mL
5 mM	0.7082 mL	3.5411 mL	7.0822 mL
10 mM	0.3541 mL	1.7705 mL	3.5411 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (254 KB) HNMR (129 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF:PBS (pH 7.2) (1:1) / Ethanol / DMSO / DMF	1 mM	3.5411 mL	17.7054 mL	35.4108 mL	88.5269 mL
Ethanol / DMSO / DMF	5 mM	0.7082 mL	3.5411 mL	7.0822 mL	17.7054 mL
	10 mM	0.3541 mL	1.7705 mL	3.5411 mL	8.8527 mL
	15 mM	0.2361 mL	1.1804 mL	2.3607 mL	5.9018 mL
DMSO / DMF	20 mM	0.1771 mL	0.8853 mL	1.7705 mL	4.4263 mL
	25 mM	0.1416 mL	0.7082 mL	1.4164 mL	3.5411 mL
	30 mM	0.1180 mL	0.5902 mL	1.1804 mL	2.9509 mL
DMF	40 mM	0.0885 mL	0.4426 mL	0.8853 mL	2.2132 mL
	50 mM	0.0708 mL	0.3541 mL	0.7082 mL	1.7705 mL
	60 mM	0.0590 mL	0.2951 mL	0.5902 mL	1.4754 mL
	80 mM	0.0443 mL	0.2213 mL	0.4426 mL	1.1066 mL
	100 mM	0.0354 mL	0.1771 mL	0.3541 mL	0.8853 mL