2. Epigenetics
  3. Epigenetic Reader Domain
  4. (Z)-JQ1-TCO

JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo.

For research use only. We do not sell to patients.

(Z)-JQ1-TCO Chemical Structure

(Z)-JQ1-TCO Chemical Structure

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50 mg USD 1333 In-stock
100 mg USD 2000 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (Z)-JQ1-TCO:

(Z)-JQ1-TCO Related Antibodies

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Description

JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo[1][2].

IC50 & Target[2]

BRD4

 

In Vitro

JQ1-TCO (10 μM; 18 h) doesn't induces significant degradation of BRD4 in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Z)-JQ1-TCO Related Antibodies
Molecular Weight

609.18

Formula

C31H37ClN6O3S
Unlabeled CAS

Appearance

Solid

Color

White to light yellow

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCCNC(OC4CCC/C=C\CC4)=O)=O)C5=NN=C(C)N25
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(Z)-JQ1-TCO Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-JQ1-TCOEpigenetic Reader DomainInhibitorinhibitorinhibit

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HY-148864A
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