2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. α-Conotoxin Im-I

α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR.

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Custom Peptide Synthesis

α-Conotoxin Im-I Chemical Structure

α-Conotoxin Im-I Chemical Structure

CAS No. : 156467-85-5

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500 μg USD 180 In-stock
1 mg USD 290 In-stock
5 mg USD 680 In-stock
10 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

α-Conotoxin Im-I Related Antibodies

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Description

α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR[1][2].

IC50 & Target

α7/α9 nAChR[1][2].
Molecular Weight

1351.56

Formula

C52H78N20O15S4
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

Sequence

Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys12)
Sequence Shortening

GCCSDPRCAWRC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys12)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (73.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7399 mL 3.6994 mL 7.3989 mL
5 mM 0.1480 mL 0.7399 mL 1.4798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7399 mL 3.6994 mL 7.3989 mL 18.4971 mL
5 mM 0.1480 mL 0.7399 mL 1.4798 mL 3.6994 mL
10 mM 0.0740 mL 0.3699 mL 0.7399 mL 1.8497 mL
15 mM 0.0493 mL 0.2466 mL 0.4933 mL 1.2331 mL
20 mM 0.0370 mL 0.1850 mL 0.3699 mL 0.9249 mL
25 mM 0.0296 mL 0.1480 mL 0.2960 mL 0.7399 mL
30 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6166 mL
40 mM 0.0185 mL 0.0925 mL 0.1850 mL 0.4624 mL
50 mM 0.0148 mL 0.0740 mL 0.1480 mL 0.3699 mL
60 mM 0.0123 mL 0.0617 mL 0.1233 mL 0.3083 mL
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α-Conotoxin Im-I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Conotoxin Im-I156467-85-5nAChRNicotinic acetylcholine receptors;nicotinic receptorsseizuresInhibitorinhibitorinhibit

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