2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Endogenous Metabolite
  4. α-Hydroxyglutaric acid-d4 disodium

α-Hydroxyglutaric acid-d4 disodium  (Synonyms: 2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium)

Cat. No.: HY-113038AS1 Assay: 95.9%
COA Handling Instructions

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α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

For research use only. We do not sell to patients.

α-Hydroxyglutaric acid-d<sub>4</sub> disodium Chemical Structure

α-Hydroxyglutaric acid-d4 disodium Chemical Structure

CAS No. : 2483831-91-8

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1 mg USD 75 In-stock
5 mg USD 190 In-stock
10 mg USD 305 In-stock
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Other Forms of α-Hydroxyglutaric acid-d4 disodium:

α-Hydroxyglutaric acid-d4 disodium Related Antibodies

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Description

α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Hydroxyglutaric acid-d4 disodium Related Antibodies
Molecular Weight

196.10

Formula

C5H2D4Na2O5
CAS No.
Unlabeled CAS

40951-21-1
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O[Na])CC([2H])([2H])C(O[2H])([2H])C(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (637.43 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0994 mL 25.4972 mL 50.9944 mL
5 mM 1.0199 mL 5.0994 mL 10.1989 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 95.9%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0994 mL 25.4972 mL 50.9944 mL 127.4860 mL
5 mM 1.0199 mL 5.0994 mL 10.1989 mL 25.4972 mL
10 mM 0.5099 mL 2.5497 mL 5.0994 mL 12.7486 mL
15 mM 0.3400 mL 1.6998 mL 3.3996 mL 8.4991 mL
20 mM 0.2550 mL 1.2749 mL 2.5497 mL 6.3743 mL
25 mM 0.2040 mL 1.0199 mL 2.0398 mL 5.0994 mL
30 mM 0.1700 mL 0.8499 mL 1.6998 mL 4.2495 mL
40 mM 0.1275 mL 0.6374 mL 1.2749 mL 3.1871 mL
50 mM 0.1020 mL 0.5099 mL 1.0199 mL 2.5497 mL
60 mM 0.0850 mL 0.4250 mL 0.8499 mL 2.1248 mL
80 mM 0.0637 mL 0.3187 mL 0.6374 mL 1.5936 mL
100 mM 0.0510 mL 0.2550 mL 0.5099 mL 1.2749 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-Hydroxyglutaric acid-d4 disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Hydroxyglutaric acid-d4 disodium2483831-91-82-Hydroxyglutarate-d4 disodium2-Hydroxyglutaric acid-d4 disodium2-Hydroxypentanedioic acid-d4 disodiumHistone DemethylaseEndogenous MetaboliteInhibitorinhibitorinhibit

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