2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. β-Nicotinamide mononucleotide-d4

β-Nicotinamide mononucleotide-d4  (Synonyms: β-NM-d4; NMN-d4)

Cat. No.: HY-F0004S Purity: 97.98%
COA Handling Instructions

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β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

For research use only. We do not sell to patients.

β-Nicotinamide mononucleotide-d<sub>4</sub> Chemical Structure

β-Nicotinamide mononucleotide-d4 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of β-Nicotinamide mononucleotide-d4:

β-Nicotinamide mononucleotide-d4 Related Antibodies

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Description

β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Nicotinamide mononucleotide-d4 Related Antibodies
Molecular Weight

338.24

Formula

C11H11D4N2O8P
Unlabeled CAS

1094-61-7
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H]([N+]2=C([2H])C([2H])=C([2H])C(C(N)=O)=C2[2H])O[C@@H]1COP(O)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

PBS (pH 7.2) : ≥ 10 mg/mL (29.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9565 mL 14.7824 mL 29.5648 mL
5 mM 0.5913 mL 2.9565 mL 5.9130 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (257 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) 1 mM 2.9565 mL 14.7824 mL 29.5648 mL 73.9120 mL
5 mM 0.5913 mL 2.9565 mL 5.9130 mL 14.7824 mL
10 mM 0.2956 mL 1.4782 mL 2.9565 mL 7.3912 mL
15 mM 0.1971 mL 0.9855 mL 1.9710 mL 4.9275 mL
20 mM 0.1478 mL 0.7391 mL 1.4782 mL 3.6956 mL
25 mM 0.1183 mL 0.5913 mL 1.1826 mL 2.9565 mL
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β-Nicotinamide mononucleotide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Nicotinamide mononucleotide-d4β-NM-d4NMN-d4Endogenous MetaboliteInhibitorinhibitorinhibit

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