2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. α-Conotoxin Vc1.1 TFA

α-Conotoxin Vc1.1 TFA is a disulfide-bonded peptide isolated from Conus victoriae and is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2, α3β2 and α3β4 with IC50s of 7.2 μM, 7.3 μM and 4.2 μM, respectively, and has less inhibitory effect on other nAChR subtypes. α-Conotoxin Vc1.1 TFA has the potential for neuropathic pain reserach.

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α-Conotoxin Vc1.1 TFA Chemical Structure

α-Conotoxin Vc1.1 TFA Chemical Structure

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α-Conotoxin Vc1.1 TFA Related Antibodies

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Description

α-Conotoxin Vc1.1 TFA is a disulfide-bonded peptide isolated from Conus victoriae and is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2, α3β2 and α3β4 with IC50s of 7.2 μM, 7.3 μM and 4.2 μM, respectively, and has less inhibitory effect on other nAChR subtypes. α-Conotoxin Vc1.1 TFA has the potential for neuropathic pain reserach[1][2].

IC50 & Target

IC50: 7.2 μM (α3α5β2), 7.3 μM (α3β2) and 4.2 μM (α3β4)[1]
In Vitro

The α-Conotoxin Vc1.1 is first discovered using a PCR screen of cDNAs from the venom ducts of Conus victoriae. α-Conotoxin Vc1.1 inhibits nicotine-evoked membrane currents in isolated bovine chromaffin cells in a concentration-dependent manner and preferentially targets peripheral nAChR subtypes over central subtypes. The three-dimensional structure of Vc1.1 comprises a small alpha-helix spanning residues Pro6 to Asp11 and is braced by the I-III, II-IV disulfide connectivity seen in other alpha-conotoxins. The cysteine spacing within the sequence of α-Conotoxin Vc1.1 suggests that it is a member of the 4/7 subclass of α-conotoxins, which includes the extensively studied conotoxins MII, EpI and PnIB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Conotoxin Vc1.1 TFA Related Antibodies
In Vivo

α-Conotoxin Vc1.1 (0.18-18 μg/μL; intramuscular injection; daily; for 7 days; male Sprague-Dawley rats) treatment suppresses pain behaviors and also accelerates functional recovery of injured neurons in CCI rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Outbred male Sprague-Dawley rats (3-4 months old; 250-350 g) bearing with chronic constriction injury (CCI)[1]
Dosage: 0.18 μg/μL, 1.8 μg/μL or 18 μg/μL
Administration: Intramuscular injection; daily; for 7 days
Result: Suppressed pain behaviors and also accelerates functional recovery of injured neurones.
Molecular Weight

1921.00

Formula

C73H104F3N23O27S4
Sequence

Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Asn-Tyr-Asp-His-Pro-Glu-Ile-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
Sequence Shortening

GCCSDPRCNYDHPEIC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Conotoxin Vc1.1 TFA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Conotoxin Vc1.1nAChRNicotinic acetylcholine receptorsAnalgesicdisulfidepeptideneuropathicα3α5β2α3β2α3β4Inhibitorinhibitorinhibit

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