1. αvβ1 integrin-IN-1

αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (αvβ1 integrin-IN-1 TFA) that retains the same biological activity.

For research use only. We do not sell to patients.

αvβ1 integrin-IN-1 Chemical Structure

αvβ1 integrin-IN-1 Chemical Structure

CAS No. : 1689540-62-2

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Description

αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects[1].

IC50 & Target

IC50: 0.63 nM (αvβ1 integrin)[1]

In Vitro

αvβ1 integrin-IN-1 (Compound C8) significantly reduces the fibrotic markers in mouse model for liver and lung fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

558.65

Formula

C26H34N6O6S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CC1=CC=C(NC(CCCCNC(N)=N)=O)C=C1)NC([C@H]2N(S(=O)(C3=CC=CC=C3)=O)CCC2)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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αvβ1 integrin-IN-1
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HY-100445
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