2. Stem Cell/Wnt
  3. β-catenin
  4. β-catenin-IN-37

β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively.

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β-catenin-IN-37 Chemical Structure

β-catenin-IN-37 Chemical Structure

CAS No. : 1783856-40-5

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β-catenin-IN-37 Related Antibodies

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Description

β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively[1].

IC50 & Target

β-catenin-IN-37 inhibits SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively.
In Vitro

β-catenin-IN-37 displays Ki values of 17 μM and 18 μM forβ-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-catenin-IN-37 Related Antibodies
Molecular Weight

307.27

Formula

C13H9N9O
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

N1(CCC2=NNN=N2)C3=NC4=NON=C4N=C3C5=C1C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (325.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2545 mL 16.2723 mL 32.5447 mL
5 mM 0.6509 mL 3.2545 mL 6.5089 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2545 mL 16.2723 mL 32.5447 mL 81.3617 mL
5 mM 0.6509 mL 3.2545 mL 6.5089 mL 16.2723 mL
10 mM 0.3254 mL 1.6272 mL 3.2545 mL 8.1362 mL
15 mM 0.2170 mL 1.0848 mL 2.1696 mL 5.4241 mL
20 mM 0.1627 mL 0.8136 mL 1.6272 mL 4.0681 mL
25 mM 0.1302 mL 0.6509 mL 1.3018 mL 3.2545 mL
30 mM 0.1085 mL 0.5424 mL 1.0848 mL 2.7121 mL
40 mM 0.0814 mL 0.4068 mL 0.8136 mL 2.0340 mL
50 mM 0.0651 mL 0.3254 mL 0.6509 mL 1.6272 mL
60 mM 0.0542 mL 0.2712 mL 0.5424 mL 1.3560 mL
80 mM 0.0407 mL 0.2034 mL 0.4068 mL 1.0170 mL
100 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8136 mL
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β-catenin-IN-37 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-catenin-IN-371783856-40-5β-cateninBeta cateninT-cellWnt signalingcolorectal cancer cellsSW480HCT116Inhibitorinhibitorinhibit

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