1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. α-Conotoxin MII

α-Conotoxin MII (Synonyms: α-CTxMII)

Cat. No.: HY-P1365
Handling Instructions

α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors .

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-Conotoxin MII Chemical Structure

α-Conotoxin MII Chemical Structure

CAS No. : 175735-93-0

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Description

α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. α-Conotoxin MII (α-CTxMII) potently blocks β3-containing neuronal nicotinic receptors [1][2][3].

IC50 & Target

IC50: 0.5 nM (α3β2)[1].

In Vitro

α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors[1][2].

Molecular Weight

1710.94

Formula

C₆₇H₁₀₃N₂₃O₂₂S₄

CAS No.

175735-93-0

Sequence

Gly-Cys-Cys-Ser-Asn-Pro-Val-Cys-His-Leu-Glu-His-Ser-Asn-Leu-Cys-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)

Sequence Shortening

GCCSNPVCHLEHSNLC-NH2 (Disulfide bridge:Cys2-Cys8;Cys3-Cys16)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

α-Conotoxin MIIα-CTxMIInAChRNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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