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β-Aminoarteether maleate (Synonyms: SM934)

Cat. No.: HY-137553A
Handling Instructions

β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases.

For research use only. We do not sell to patients.

β-Aminoarteether maleate Chemical Structure

β-Aminoarteether maleate Chemical Structure

CAS No. : 133162-25-1

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Description

β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases[1].

In Vitro

β-Aminoarteether (SM934;10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation[1].
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NZB/W F1 mice (Six and half months old)[1]
Dosage: 1 mg/kg, 3 mg/kg, and 10 mg/kg
Administration: Oral administration; daliy; for 3 months
Result: Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice.
Molecular Weight

443.49

Formula

C₂₁H₃₃NO₉

CAS No.

133162-25-1

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

β-AminoarteetherSM934SM 934SM-934OthersIL-10Artemisininanti-inflammatoryautoimmunelupusdiseasesInhibitorinhibitorinhibit

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β-Aminoarteether maleate
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