1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. β-Pompilidotoxin TFA

β-Pompilidotoxin TFA (Synonyms: β-PMTX TFA)

Cat. No.: HY-P1084A
Handling Instructions

β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Pompilidotoxin TFA Chemical Structure

β-Pompilidotoxin TFA Chemical Structure

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Other Forms of β-Pompilidotoxin TFA:

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Description

β-Pompilidotoxin TFA (β-PMTX TFA), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells[1].

In Vitro

β-Pompilidotoxin TFA (β-PMTX TFA) increases resurgent current in wild-type neurons and induced resurgent current in med neurons. β-Pompilidotoxin TFA (10 μM) modestly but significantly increased the decay time constant (τdecay) of currents evoked by a step from -90 to 0 mV from 0.52 to 0.73 msec in wild-type Purkinje cells[1].

Molecular Weight

1671.90

Formula

C₇₃H₁₂₅F₃N₂₂O₁₉

Sequence

Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-NH2

Sequence Shortening

RIKIGLFDQLSRL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

β-Pompilidotoxinβ-PMTXSodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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β-Pompilidotoxin TFA
Cat. No.:
HY-P1084A
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