1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. CHF5407

CHF5407 

Cat. No.: HY-U00302
Handling Instructions

CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity.

For research use only. We do not sell to patients.

CHF5407 Chemical Structure

CHF5407 Chemical Structure

CAS No. : 1004312-94-0

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Description

CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity[1].

IC50 & Target

human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors[1]

In Vitro

CHF5407 has a very slow dissociation from M3 receptors (hM3; t1/2=166 min) and markedly short-acting at M2 receptors (hM2; t1/2=31 min)[1].
CHF5407 produces a potent (pIC50=9.0-9.6) and long-lasting (up to 24 h) inhibition of M3 receptor-mediated contractile responses to carbachol in the guinea pig isolated trachea and human isolated bronchus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CHF5407 (0.1, 0.3, 1 nmol/kg; intratracheally; 100 ul; sigle dose) exerted a dose-dependent and potent inhibition of ACh-induced (20 g/kg; i.v.) bronchospasm, with an ED50 value of 0.15 nmol/kg in guinea pigs (450-550 g)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

613.46

Formula

C₂₇H₂₅BrF₄N₂O₃S

CAS No.

1004312-94-0

SMILES

O=C(C1=CC=CS1)C[N+]23C[[email protected]@H](C(CC3)CC2)OC(N(C4=CC(F)=CC=C4)CC5=CC(F)=C(F)C(F)=C5)=O.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CHF5407CHF 5407CHF-5407mAChRMuscarinic acetylcholine receptormuscarinicM3hM1hM2hM3antibronchospasticInhibitorinhibitorinhibit

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CHF5407
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HY-U00302
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