Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

1-NM-PP1

HY-13942

(PP1 Analog II; 1-NM-PP 1)

1-NM-PP1

1-NM-PP1 Chemical Structure

1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $105 In-stock
5 mg $95 In-stock
10 mg $150 In-stock
50 mg $580 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €103 In-stock
5 mg €93 In-stock
10 mg €147 In-stock
50 mg €568 In-stock
100 mg Get quote
200 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: 1-NM-PP1
Cat. No.: HY-13942

1-NM-PP1 Data Sheet

  • View current batch:

    Purity: 98.02%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Customer View

Related Compound Libraries

Biological Activity of 1-NM-PP1

1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).
IC50 Value: 4.2 nM (v-Src-as1 I338G) [1]
Target: Src Family Kinase
PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. 1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive', as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for CDK2-as1 versus 29 μM for CDK2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems. In addition it has been shown to activate mutants of Ire1, a transmembrane kinase.
 

Chemical Information

M.Wt 331.41 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₀H₂₁N₅
CAS No 221244-14-0
Solvent & Solubility

DMSO: ≤ 27.5 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.0174 mL 15.0871 mL 30.1741 mL
5 mM 0.6035 mL 3.0174 mL 6.0348 mL
10 mM 0.3017 mL 1.5087 mL 3.0174 mL

References on 1-NM-PP1

Inhibitor Kit

Related CDK Products

  • AMG 925

    AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell.

  • AZD-5438

    AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM. It is less potent to CDK5/6.

  • BIO

    6-BIO(6-Bromoindirubin-3(acute)-oxime) is a potent and selective inhibitor of GSK-3 and CDK1–cyclinB complex with IC50 of 5 nM /320 nM/83 nM for GSK-3(alpha)(beta)/CDK1/CDK5 respectively.

  • BMS-265246

    BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively.

  • Briciclib

    Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells.

  • Ca2+ channel agonist 1

    Ca2(addition) channel agonist 1 is a N-type Ca2(addition) channel activity agonist, with EC50 of 14.23 uM, also inhibits cdk2 kinase activity with EC50 of 3.34 uM.

  • CDK-IN-2

    CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM.

  • CDK9-IN-1

    CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection.

  • CDK9-IN-2

    CDK9-IN-2 is a novel cyclin-dependent kinase 9(CDK9) inhibitor.

  • CDK9-IN-6

    CDK9-IN-6 is a CDK9 inhibitor, refers to Example 399 in WO 2012101062 A1

MORE