1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. FAAH
  3. 11C-MK-3168

11C-MK-3168 

Cat. No.: HY-111394
Handling Instructions

11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.

For research use only. We do not sell to patients.

11C-MK-3168 Chemical Structure

11C-MK-3168 Chemical Structure

CAS No. : 1242441-58-2

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Description

11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.

IC50 & Target

IC50: 1.0 nM (Human FAAH), 1.7 nM (Rat FAAH), 5.5 nM (Rhesus FAAH)[1]

In Vitro

11C-MK-3168 is a potent and reversible fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively. 11C-MK-3168 also shows selectivity over hERG (IC50 = 37 μM) and DLZ (IC50 = 16 μM); CYP 3A4 (IC50 > 50 μM); and the two cannabinoid receptors, CB1 (IC50 = 30 μM) and CB2 (IC50 = 150 μM)[1].

Clinical Trial
Molecular Weight

411.94

Formula

C₂₀ ₁₁CH₂₁ClN₄OS

CAS No.

1242441-58-2

SMILES

ClC1=CN=C(SC2=C(C3=CC=C([[email protected]]4C[[email protected]@H]4C(N(C)C)=O)C=C3)N=CN2[11CH3])C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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11C-MK-3168
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