1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. FAAH

11C-MK-3168 

Cat. No.: HY-111394
Handling Instructions

11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.

For research use only. We do not sell to patients.

11C-MK-3168 Chemical Structure

11C-MK-3168 Chemical Structure

CAS No. : 1242441-58-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.

IC50 & Target

IC50: 1.0 nM (Human FAAH), 1.7 nM (Rat FAAH), 5.5 nM (Rhesus FAAH)[1]

In Vitro

11C-MK-3168 is a potent and reversible fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively. 11C-MK-3168 also shows selectivity over hERG (IC50 = 37 μM) and DLZ (IC50 = 16 μM); CYP 3A4 (IC50 > 50 μM); and the two cannabinoid receptors, CB1 (IC50 = 30 μM) and CB2 (IC50 = 150 μM)[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4275 mL 12.1377 mL 24.2754 mL
5 mM 0.4855 mL 2.4275 mL 4.8551 mL
10 mM 0.2428 mL 1.2138 mL 2.4275 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

411.94

Formula

C₂₀ ₁₁CH₂₁ClN₄OS

CAS No.

1242441-58-2

SMILES

ClC1=CN=C(SC2=C(C3=CC=C([[email protected]]4C[[email protected]@H]4C(N(C)C)=O)C=C3)N=CN2[11CH3])C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
11C-MK-3168
Cat. No.:
HY-111394
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11C-MK-3168

Cat. No.: HY-111394