1. Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. PPAR Endogenous Metabolite
  3. 15-Deoxy-Δ-12,14-prostaglandin J2

15-Deoxy-Δ-12,14-prostaglandin J2  (Synonyms: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2)

Cat. No.: HY-108568 Purity: ≥99.0%
COA Handling Instructions

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.

For research use only. We do not sell to patients.

15-Deoxy-Δ-12,14-prostaglandin J2 Chemical Structure

15-Deoxy-Δ-12,14-prostaglandin J2 Chemical Structure

CAS No. : 87893-55-8

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Solvent
1 mg (3.16 mM * 1 mL in Methyl acetate) USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE 15-Deoxy-Δ-12,14-prostaglandin J2

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Description

15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

IC50 & Target[1]

PPARγ

2 μM (EC50)

PPARδ

 

Human Endogenous Metabolite

 

In Vitro

15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.43

Formula

C20H28O3

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥99.0%

References
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15-Deoxy-Δ-12,14-prostaglandin J2
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