1. GPCR/G Protein
  2. Leukotriene Receptor
  3. LTD4 antagonist 1

LTD4 antagonist 1 

Cat. No.: HY-U00359
Handling Instructions

LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

For research use only. We do not sell to patients.

LTD4 antagonist 1 Chemical Structure

LTD4 antagonist 1 Chemical Structure

CAS No. : 136564-67-5

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Description

LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

IC50 & Target[1]

LTD4

0.57 nM (Ki)

In Vitro

LTD4 antagonist 1 (Compound 38b) exhibits a Ki of 0.57 nM for displacement of [3H]LTD4 on guinea pig lung membranes, a pKB of 9.93±0.14 versus LTE4 on guinea pig trachea[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

615.66

Formula

C₃₁H₃₂F₃N₃O₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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LTD4 antagonist 1
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HY-U00359
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