1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. 5-HT6/7 antagonist 1

5-HT6/7 antagonist 1 

Cat. No.: HY-101622
Handling Instructions

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.

For research use only. We do not sell to patients.

5-HT6/7 antagonist 1 Chemical Structure

5-HT6/7 antagonist 1 Chemical Structure

CAS No. : 131999-28-5

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Description

5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels.

IC50 & Target

5-HT6 Receptor

 

5-HT7 Receptor

 

5-HT2A Receptor

 

D2 Receptor

 

In Vitro

Targeting 5-HT6 and/ or 5-HT7 receptors with antagonist drugs could constitute a promising strategy for treating symptoms of BPSD while avoiding some of the side effects of current antipsychotic drugs. Nevertheless, due to the complex pathology of dementia and accompanying behavioral and psychological symptoms, it seems unlikely that focusing on a single therapeutic target would be sufficient to provide adequate clinical benefit, and it is likely that successful development of novel anti-BPSD agents should involve a “designed” multifactorial approach[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

393.41

Formula

C₂₂H₂₀FN₃O₃

CAS No.

131999-28-5

SMILES

O=C1N(CCN2CCC(C3=NOC4=C3C=CC(F)=C4)CC2)C(C5=C1C=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

5-HT6/7 antagonist 15-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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Product Name:
5-HT6/7 antagonist 1
Cat. No.:
HY-101622
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