1. Metabolic Enzyme/Protease
  2. Thrombin
  3. Thrombin inhibitor 1

Thrombin inhibitor 1 

Cat. No.: HY-U00370
Handling Instructions

Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).

For research use only. We do not sell to patients.

Thrombin inhibitor 1 Chemical Structure

Thrombin inhibitor 1 Chemical Structure

CAS No. : 855998-46-8

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Description

Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).

IC50 & Target

Ki: 0.66 nM (thrombin)[1]

In Vitro

Thrombin inhibitor 1 (Compound 4) is binds in the active site of thrombin with Ki of 0.66 nM, 2xaPTT=0.43 uM). Thrombin inhibitor 1 (Compound 4) is evaluated for its thrombin inhibitory potency and its functional ability to double the activated partial thromboplastin time (2xaPTT) in human plasma with a 2xaPTT of 0.43 μM[1].

Molecular Weight

497.32

Formula

C₂₂H₂₀Cl₂F₂N₄O₃

CAS No.

855998-46-8

SMILES

C[[email protected]](C1=CC(Cl)=CC=C1)NC(CC2=C(Cl)C=CC(NCC(F)(C3=CC=CC=N3=O)F)=N2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Thrombin inhibitor 1
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HY-U00370
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