1. Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. PGE synthase
    5-Lipoxygenase
  3. PGS-IN-1

PGS-IN-1 (Synonyms: KME-4)

Cat. No.: HY-101587 Purity: 99.51%
Handling Instructions

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.

For research use only. We do not sell to patients.

PGS-IN-1 Chemical Structure

PGS-IN-1 Chemical Structure

CAS No. : 102271-49-8

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1 mg USD 240 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
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Description

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.

IC50 & Target

IC50: 0.28 μM (PGS), 1.05 μM (5-lipoxygenase)[1]

In Vitro

The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM)[1].

Molecular Weight

302.41

Formula

C₁₉H₂₆O₃

CAS No.

102271-49-8

SMILES

O=C1OCC/C1=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Kinase Assay
[1]

PGS-IN-1 is dissolved in ethanol and the final concentration of ethanol is kept at 2% in each assay. The reaction mixture includes reaction buffer, enzyme (20 μg protein), and PGS-IN-1 in a total volume of 0.2 mL. The mixture is incubated for 15 min at 37°C with shaking and terminated by the addition of 2.5 mL ethyl acetate and 25 μL 1 N formic acid[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Rats: PGS-IN-1 is administered orally to groups of 4-6 male Wistar rats weighting 160-220 g. One hour later, 1 % carrageenin in 0.9 % NaCl is injected subcutaneously into a hind paw. Paw volumes are measured 5 h after the injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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PGS-IN-1
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