2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin  (Synonyms: Anhydroepitetrodotoxin)

Cat. No.: HY-126985 Purity: ≥98.0%
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4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6.

For research use only. We do not sell to patients.

4,9-Anhydrotetrodotoxin Chemical Structure

4,9-Anhydrotetrodotoxin Chemical Structure

CAS No. : 13072-89-4

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100 μg USD 850 In-stock

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Based on 1 publication(s) in Google Scholar

4,9-Anhydrotetrodotoxin Related Antibodies

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Description

4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].

In Vitro

4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4,9-Anhydrotetrodotoxin Related Antibodies
Molecular Weight

301.25

Formula

C11H15N3O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@]1(O2)[C@@]3([H])OC(C45)NC(N)=N[C@@]43[C@H](O)[C@@]2([H])[C@@](CO)(O)C5O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

COA (257 KB)

Handling Instructions (2659 KB)
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4,9-Anhydrotetrodotoxin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4,9-Anhydrotetrodotoxin13072-89-4AnhydroepitetrodotoxinSodium ChannelNa channelsNa+ channelsVGSCNav1.1Nav1.6Inhibitorinhibitorinhibit

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