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4-defluoro-4-1h-1-2-4-triazol-1-yl-fluconazole-d4

" in MedChemExpress (MCE) Product Catalog:

34

Inhibitors & Agonists

2

Biochemical Assay Reagents

4

Peptides

2

Natural
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3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W027592
    1H-1,2,4-Triazol-3-amine

    		Biochemical Assay Reagents Others
    1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.
    1H-1,2,4-<em>Triazol</em>-3-amine
  • HY-B0101
    Fluconazole
    Maximum Cited Publications
    10 Publications Verification

    UK-49858

    		 Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
    <em>Fluconazole</em>
  • HY-B0101S
    Fluconazole-d4

    UK-49858-d4

    		 Fungal Antibiotic Infection
    Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
    <em>Fluconazole</em>-d4
  • HY-W141862
    β-(1,2,4-Triazol-3-yl)-DL-alanine

    		Amino Acid Derivatives Others
    β-(1,2,4-Triazol-3-yl)-DL-alanine is an alanine derivative .
    β-(1,2,4-<em>Triazol</em>-3-yl)-DL-alanine
  • HY-B0101A
    Fluconazole hydrate

    UK 49858 hydrate

    		 Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
    <em>Fluconazole</em> hydrate
  • HY-B0101B
    Fluconazole mesylate

    UK 49858 mesylate

    		 Fungal Antibiotic Bacterial Infection Cancer
    Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
    <em>Fluconazole</em> mesylate
  • HY-W329835S
    2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5

    		Isotope-Labeled Compounds Others
    2-((1H-1,2,4-Triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5 is the deuterium labeled 2-((1H-1,2,4-triazol-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile[1].
    2-((1H-1,2,4-<em>Triazol</em>-1-yl)methyl)-4-(4-chlorophenyl)-2-phenylbutanenitrile-d5
  • HY-W012383
    1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

    		Biochemical Assay Reagents Others
    1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1-(2,4-Difluorophenyl)-2-(1H-1,2,4-<em>triazol</em>-1-yl)ethanone
  • HY-147238
    Antifungal agent 35

    		Fungal Infection
    Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans .
    Antifungal agent 35
  • HY-155198
    Antifungal agent 72

    		Fungal Infection
    Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research .
    Antifungal agent 72
  • HY-145873
    BI-10

    		Fungal Infection
    BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability .
    BI-10
  • HY-155279
    Antifungal agent 73

    		Fungal Infection
    Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains .
    Antifungal agent 73
  • HY-150583
    Chitin synthase inhibitor 2

    		Fungal Antibiotic Inflammation/Immunology
    Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .
    Chitin synthase inhibitor 2
  • HY-W110148S
    Amitrole-13C,15N2

    		Isotope-Labeled Compounds Others
    Amitrole- 13C, 15N 2is the deuterium labeled4H-1,2,4-Triazol-3-amine(HY-W110148) .
    Amitrole-13C,15N2
  • HY-116686
    Inz-1

    		Cytochrome P450 Fungal Infection
    Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans .
    Inz-1
  • HY-100666
    Fosfluconazole

    		Fungal Infection
    Fosfluconazole is a proagent of Fluconazole that is widely used as an antifungal agent.
    Fosfluconazole
  • HY-156090
    PK-10

    		Mitochondrial Metabolism Fungal Infection
    PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .
    PK-10
  • HY-141812
    Antifungal agent 12

    		Fungal Infection
    Antifungal agent 12 is a novel fluconazole-based compound with promising antifungal activities.
    Antifungal agent 12
  • HY-132925
    Antifungal agent 16

    		Fungal Infection
    Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively.
    Antifungal agent 16
  • HY-143406
    Antifungal agent 25

    		Fungal Infection
    Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo .
    Antifungal agent 25
  • HY-162271
    Antibacterial agent 187

    		Topoisomerase Fungal Infection
    Antibacterial agent 187 (IKE7) is a derivative containing imidazole and triazolacridone structures that target yeast topoisomerase II. Antibacterial agent 187 has antifungal activity and MIC value of resistance to fluconazole (HY-B0101) is 32-64 μg/mL .
    Antibacterial agent 187
  • HY-146024
    Antifungal agent 28

    		Fungal Infection
    Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
    Antifungal agent 28
  • HY-P2496
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled

    		Endothelin Receptor Cardiovascular Disease
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB .
    Endothelin 1 (swine, human), Alexa <em>Fluor</em> 488-labeled
  • HY-153619
    Antifungal agent 54

    		Fungal Infection
    Antifungal agent 54 (compound A05) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 54 is more effective than Miconazole (HY-B0454). Antifungal agent 54 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .
    Antifungal agent 54
  • HY-153620
    Antifungal agent 55

    		Fungal Infection
    Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .
    Antifungal agent 55
  • HY-153622
    Antifungal agent 57

    		Fungal Infection
    Antifungal agent 57 (compound A19) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 57 is more effective than Miconazole (HY-B0454). Antifungal agent 57 inhibits Candida albicans strains with MIC values of 0.5-2 μg/mL .
    Antifungal agent 57
  • HY-153623
    Antifungal agent 58

    		Fungal Infection
    Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candida albicans strains with MIC values of 0.06-8 μg/mL .
    Antifungal agent 58
  • HY-P5372
    Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

    		Protease Activated Receptor (PAR) Others
    Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)
    Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
  • HY-153621
    Antifungal agent 56

    		Fungal Infection
    Antifungal agent 56 (compound A09) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 56 is more effective than Miconazole (HY-B0454). Antifungal agent 56 inhibits Candida albicans strains with MIC values of 0.03-0.25 μg/mL .
    Antifungal agent 56
  • HY-151410
    Chitin synthase inhibitor 5

    		Fungal Infection
    Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .
    Chitin synthase inhibitor 5
  • HY-155545
    Antifungal agent 60

    		Fungal Infection
    Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antifungal agent 60
  • HY-146464
    Antifungal agent 30

    		Fungal Infection
    Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .
    Antifungal agent 30
  • HY-N10401
    Batzelladine D

    		Fungal Bacterial Parasite Infection Cancer
    Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC50 of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .
    Batzelladine D
  • HY-N10402
    Norbatzelladine L

    		Fungal Bacterial Parasite Infection Cancer
    Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC50 of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .
    Norbatzelladine L

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