Lipid peroxidation inhibitor 1

Cat. No.: HY-U00319: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC₅₀ of 0.07 μM.

For research use only. We do not sell to patients.

Lipid peroxidation inhibitor 1 Chemical Structure

CAS No. : 142873-41-4

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description	Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC₅₀ of 0.07 μM.
IC₅₀ & Target	IC50: 0.07μM (lipid peroxidation)^[1]
In Vitro	Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC₅₀ of 0.07 μM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Lipid peroxidation inhibitor 1 Related Antibodies
In Vivo	Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	364.52
Formula	C₂₄H₃₂N₂O
CAS No.	142873-41-4
SMILES	NC1=C(C)C(C)=C(OC(CN2CCC(C3=CC=CC=C3)CC2)(C)C4)C4=C1C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Ohkawa S, et al. 5-aminocoumarans: dual inhibitors of lipid peroxidation and dopamine release with protectiveeffects against central nervous system trauma and ischemia. J Med Chem. 1997 Feb 14;40(4):559-73. [Content Brief]

Cell Assay ^[1]	To rat liver microsomes (S-9) (0.3 mg of protein/40 mM Tris-malate buffer (pH 7.4), 2.4 mL) (2.4 mL) is added a mixture (1:1; 0.1 mL) of aqueous FeCl₂ solution (0.25 mM) and NADPH (3 mM). After incubation of the homogenate for 1 h at 37 °C, peroxide production is determined by the thiobarbituric acid method. The inhibitory activities on lipid peroxidation are expressed as IC₅₀ values or percent inhibition as compare with the amount of production in the vehicle (DMSO) group^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Five-week old male mice (25 to 35 g) are used. Following a 90 min acclimation period, the test compounds (including Lipid peroxidation inhibitor 1) suspended in 5% gum arabic are injected intraperitoneally in a volume of 20 mL/kg. Thirty minutes after treatment with test compounds, methamphetamine dissolved in saline is injected intraperitoneally at a dose of 1 mg/kg in a volume of 20 mL/kg. Immediately after methamphetamine injection, spontaneous motor activity is monitored for 90 min^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Ohkawa S, et al. 5-aminocoumarans: dual inhibitors of lipid peroxidation and dopamine release with protectiveeffects against central nervous system trauma and ischemia. J Med Chem. 1997 Feb 14;40(4):559-73. [Content Brief]

Lipid peroxidation inhibitor 1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipid peroxidation inhibitor 1142873-41-4Lipid peroxidation inhibitor1Lipid peroxidation inhibitor-1OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Email Address *
Phone Number			Department *
Organization Name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Lipid peroxidation inhibitor 1

Lipid peroxidation inhibitor 1 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Protocol

Purity & Documentation

References

Customer Review