1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

6-Alpha Naloxol (Synonyms: Alpha-Naloxol)

Cat. No.: HY-12799
Handling Instructions

6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist closely related to naloxone; a human metabolite of naloxone.

For research use only. We do not sell to patients.
6-Alpha Naloxol Chemical Structure

6-Alpha Naloxol Chemical Structure

CAS No. : 20410-95-1

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10 mg USD 960 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist closely related to naloxone; a human metabolite of naloxone. IC50 value: Target: opioid antagonist When responding over the entire 30 min operant session was examined, naloxone was only 5-fold more potent than 6-alpha-naloxol in suppressing operant responding under Morphine Na?ve conditions, but this increased to a 65-fold potency difference after Single or Repeat Morphine pretreatment. Examination of the relative potency of these antagonists in the Early Phase of operant testing (5-15 min post-antagonist) revealed an even greater 100-fold potency difference between naloxone and 6-alpha-naloxol, but in the Late Phase of testing (25-35 min post-antagonist), this had declined to a 9-fold potency difference, comparable to the relative potency of naloxone to 6-alpha-naloxol under Morphine-Na?ve conditions.

References
Molecular Weight

329.39

Formula

C₁₉H₂₃NO₄

CAS No.

20410-95-1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
6-Alpha Naloxol
Cat. No.:
HY-12799
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