1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

6-Alpha Naloxol (Synonyms: Alpha-Naloxol)

Cat. No.: HY-12799
Handling Instructions

6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist closely related to naloxone; a human metabolite of naloxone.

For research use only. We do not sell to patients.

6-Alpha Naloxol Chemical Structure

6-Alpha Naloxol Chemical Structure

CAS No. : 20410-95-1

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1 mg USD 144 Get quote
5 mg USD 540 Get quote
10 mg USD 960 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

6-Alpha Naloxol(Alpha-Naloxol) is an opioid antagonist closely related to naloxone; a human metabolite of naloxone. IC50 value: Target: opioid antagonist When responding over the entire 30 min operant session was examined, naloxone was only 5-fold more potent than 6-alpha-naloxol in suppressing operant responding under Morphine Na?ve conditions, but this increased to a 65-fold potency difference after Single or Repeat Morphine pretreatment. Examination of the relative potency of these antagonists in the Early Phase of operant testing (5-15 min post-antagonist) revealed an even greater 100-fold potency difference between naloxone and 6-alpha-naloxol, but in the Late Phase of testing (25-35 min post-antagonist), this had declined to a 9-fold potency difference, comparable to the relative potency of naloxone to 6-alpha-naloxol under Morphine-Na?ve conditions.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0359 mL 15.1796 mL 30.3591 mL
5 mM 0.6072 mL 3.0359 mL 6.0718 mL
10 mM 0.3036 mL 1.5180 mL 3.0359 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

329.39

Formula

C₁₉H₂₃NO₄

CAS No.

20410-95-1

SMILES

O[[email protected]@]12[[email protected]]3([[email protected]@H](O4)[[email protected]@H](O)CC2)C5=C4C(O)=CC=C5C[[email protected]]1N(CC=C)CC3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
6-Alpha Naloxol
Cat. No.:
HY-12799
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6-Alpha Naloxol

Cat. No.: HY-12799