Search Result
Results for "
6-carboxy-5-4-5-6-simvastatin-d6
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
8
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-115292
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Tenivastatin sodium; simvastatin Impurity A sodium
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HMG-CoA Reductase (HMGCR)
Reactive Oxygen Species
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Cardiovascular Disease
Inflammation/Immunology
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Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
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- HY-135404
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- HY-119695
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Tenivastatin
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HMG-CoA Reductase (HMGCR)
Reactive Oxygen Species
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Cardiovascular Disease
Cancer
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Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
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- HY-135405
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- HY-136345
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Drug Metabolite
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Others
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(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
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- HY-136344
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Drug Metabolite
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Others
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Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
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- HY-17502R
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- HY-17502S1
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-
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- HY-119695A
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Tenivastatin ammonium
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HMG-CoA Reductase (HMGCR)
Reactive Oxygen Species
|
Cardiovascular Disease
Inflammation/Immunology
|
Simvastatin acid (Tenivastatin) ammonium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid ammonium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid ammonium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
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-
- HY-119695B
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Tenivastatin calcium hydrate
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HMG-CoA Reductase (HMGCR)
Reactive Oxygen Species
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Cardiovascular Disease
Inflammation/Immunology
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Simvastatin acid (Tenivastatin) calcium hydrate is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid calcium hydrate reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid calcium hydrate can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
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- HY-110231
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-
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- HY-17502S
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-
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- HY-135402
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-
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- HY-17502
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-
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- HY-119695AS
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Tenivastatin-d6 ammonium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
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Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
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- HY-132636S
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- HY-132617S
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-
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- HY-142842S
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-
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- HY-W023023
-
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Others
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Others
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3-Carboxy-6-hydroxycoumarin is an intermediate in organic syntheses .
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- HY-D0114
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-
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- HY-D0054
-
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Fluorescent Dye
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Inflammation/Immunology
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9-(2-Carboxy-2-cyanovinyl)julolidine is a fluorescent molecular rotor. 9-(2-Carboxy-2-cyanovinyl)julolidine can be used to bind to IgG and Fab, and preparing antibodies .
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- HY-D2183
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Fluorescent Dye
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Others
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6-Carboxy-JF5252 is a fluorophore. 6-Carboxy-JF5252 can be used as probes, dyes, tags. 6-Carboxy-JF5252 can be used for the research of super-resolution imaging .
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- HY-18734A
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- HY-18734
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-
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- HY-D1078
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Reactive Oxygen Species
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Others
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5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture
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- HY-N8139
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Others
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Metabolic Disease
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2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria .
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- HY-D1094
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SNARF 1
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Fluorescent Dye
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Others
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Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement of intracellular pH .
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- HY-112680A
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G-quadruplex
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Cancer
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Carboxy pyridostatin trifluoroacetate salt has the peculiarity to exhibit high molecular specificity for RNA over DNA G4s .
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- HY-D0050
-
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Fluorescent Dye
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Others
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5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester (cDCFDASE) is a fluorescent probe. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester can be used to evaluate the intracellular pH (pHin) of living cells at a medium pH (pHex) .
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- HY-D0194
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Fluorescent Dye
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Others
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5(6)-Carboxy-2',7'-dichlorofluorescein is an ideal substrate for MRP2 vesicular transport assay, with excellent detection and transport properties .
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- HY-W751932
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Biochemical Assay Reagents
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Others
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Carboxy-EG6-undecanethiol is an alkanethiol that suitable for self-assembly a gold thin-film substrate. Carboxy-EG6-undecanethiol can selectively capture HbA1c in sample by covalent coupling of 3-aminophenyl boronic acid (3-APBA) .
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- HY-152320
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Nucleoside Antimetabolite/Analog
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Others
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Adenosine-2-carboxy methyl amide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-150220
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Liposome
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Others
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1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can be used for the synthesis of phospholipid vesicle and improve the encapsulation efficiency of proteins .
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- HY-100836
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Trans-4-Carboxy-L-prolineis a selective glutamate transporter inhibitor .
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- HY-141302
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PROTAC Linkers
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Cancer
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Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140168
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PROTAC Linkers
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Cancer
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Carboxy-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140167
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PROTAC Linkers
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Cancer
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Carboxy-PEG2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140169
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PROTAC Linkers
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Cancer
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Carboxy-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-D1093
-
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Fluorescent Dye
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Others
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Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
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- HY-D1972
-
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Fluorescent Dye
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Others
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ATTO 610 Carboxy is a carboxyl derivative of ATTO 610 with maximum excitation/emission wavelengths: 616/633 nm.
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- HY-D1975
-
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Fluorescent Dye
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Others
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ATTO 725 Carboxy is a carboxyl derivative of ATTO 725, the maximum excitation/emission wavelength is: 728/751 nm.
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- HY-D1980
-
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Fluorescent Dye
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Others
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ATTO 620 Carboxy is a carboxyl derivative of ATTO 620, the maximum excitation/emission wavelength is: 620/642 nm.
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- HY-D2045
-
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Fluorescent Dye
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Others
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ATTO 532 carboxy is a carboxyl derivative of ATTO 532, the maximum excitation/emission wavelength is: 532/552 nm.
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- HY-D2057
-
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Fluorescent Dye
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Others
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ATTO 700 carboxy is a carboxyl derivative of ATTO 700 with maximum excitation/emission wavelengths: 700/716 nm.
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- HY-D2072
-
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Fluorescent Dye
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Others
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ATTO 680 carboxy is a carboxyl derivative of ATTO 680, the maximum excitation/emission wavelength is: 681/698 nm.
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- HY-D2018
-
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Fluorescent Dye
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Others
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ATTO 550 carboxy is a carboxyl derivative of ATTO 550 with maximum excitation/emission wavelengths: 554/576 nm.
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- HY-D2061
-
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Fluorescent Dye
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Others
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ATTO 740 carboxy is a carboxyl derivative of ATTO 740, the maximum excitation/emission wavelength is: 743/763 nm.
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- HY-141303
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PROTAC Linkers
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Cancer
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Carboxy-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-133675S
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MECPP-d4
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Isotope-Labeled Compounds
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Others
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Mono(5-carboxy-2-ethylpentyl) phthalate-d4 (MECPP-d4) is a deuterium labeled Mono(5-carboxy-2-ethylpentyl) phthalate (HY-133675). Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
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- HY-113483
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20-COOH LTB4
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Drug Metabolite
Leukotriene Receptor
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Metabolic Disease
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20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis) .
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- HY-N4153
-
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Others
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Others
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1-Methyl-2, 8-dihydroxy3-carboxy-9, 10-anthraquinone (compound 2) is compound isolated from the roots of Rheum palmatum .
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- HY-133675
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MECPP
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Drug Metabolite
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Others
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Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
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- HY-132834S
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- HY-D0045
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5-ROX, SE
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Fluorescent Dye
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Others
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5-Carboxy-X-rhodamin N-succinimidyl ester (5-ROX, SE) is a labeling reagent. 5-Carboxy-X-rhodamin N-succinimidyl ester can be used in the preparation of charge-modified dye-labeled Dideoxynucleotide Triphosphates (ddNTP) to "direct-load" DNA sequencing .
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- HY-D1086
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6-ROX, SE
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DNA Stain
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Others
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6-Carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) is a fluorescent dye for oligonucleotide labeling and automated DNA sequencing .
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- HY-D0053A
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6-carboxy-X-rhodamine hydrochloride
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Fluorescent Dye
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Others
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6-ROX (6-Carboxy-X-rhodamine) hydrochloride, a fluorescent marker of oligonucleotides, acts as a receptor coupled to 5-FAM and as a donor in FRET imaging. Excitation wavelength: 568 nm. Emission wavelength: 568 nm.
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- HY-100840
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(S)-4-carboxy-3-hydroxyphenylglycine
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mGluR
|
Neurological Disease
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(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice .
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- HY-D0784
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5-ROX
1 Publications Verification
5-carboxy-X-rhodamine
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Fluorescent Dye
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Others
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5-ROX (5-Carboxy-X-rhodamine), a rhodamine dye, exhibits strong fluorescence property in aqueous buffer with the λexit of 580 nm (ε=3.6×10 4 M -1 cm -1), and λemit of 604 nm (=0.94) .
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- HY-157918
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20-(16-Mercaptohexadecanyloxy)-3,6,9,12,15,18-hexaoxaeicosanoic acid
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Biochemical Assay Reagents
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Others
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Carboxy-EG6-hexadecanethiol is a biochemical assay reagent and can be used for chemical synthesis .
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- HY-117581
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6-Oxo simvastatin; Iso-simvastatin-6-one
|
HMG-CoA Reductase (HMGCR)
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Metabolic Disease
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L-669,262, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC50 of 0.10 ng/mL for rat liver HMG-CoA .
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- HY-W250721D
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carboxy polymethylene
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Biochemical Assay Reagents
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Others
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Carbomer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-W250721E
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carboxy polymethylene (copolymer)
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Biochemical Assay Reagents
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Others
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Carbomer copolymer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-W250721F
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carboxy polymethylene (homopolymer)
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Biochemical Assay Reagents
|
Others
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Carbomer homopolymer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-W250721G
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carboxy polymethylene (interpolymer)
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Biochemical Assay Reagents
|
Others
|
Carbomer interpolymer can be used as an excipient, such as Bioadhesives, emulsifiers, release modifiers, suspending agents, tablet binders, viscosity enhancers, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-D1774
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- HY-D0053
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6-carboxy-X-rhodamine
|
Fluorescent Dye
|
Others
|
6-ROX, a fluorescent marker of oligonucleotides, acts as a receptor coupled to 5-FAM and as a donor in FRET imaging. Excitation wavelength: 568nm. Emission wavelength: 568nm.
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- HY-133154
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CAIR; 4-carboxy-AIR
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Endogenous Metabolite
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Infection
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Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
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- HY-W001084
-
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Others
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Others
|
Methyl 4-hydroxyphenylacetate, a natural compound, is a methyl ester resulting from the formal condensation of the carboxy group of 4-Hydroxyphenylacetic acid with methanol .
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- HY-W004289
-
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Others
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Others
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Methyl pentadecanoate is a fatty acid ester, can be isolated from L. wallichi extracts. Methyl pentadecanoate is obtained by condensation of the carboxy group of pentadecanoic acid with the hydroxy group of methanol .
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- HY-113071
-
-
- HY-D0043
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5(6)-carboxy-X-rhodamine
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DNA Stain
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Others
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5(6)-ROX is a nucleic acid fluorescent label which can be used as a reference dye for real-time polymerase chain reaction.
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- HY-G0024A
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Vildagliptin carboxy acid metabolite TFA
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Cytochrome P450
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Metabolic Disease
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Vildagliptin carboxylic acid metabolite (M20.7) TFA is a potent P450 enzyme activity inhibitor .
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- HY-W011297
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Arachidonic acid methyl ester
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Others
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Metabolic Disease
|
Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
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- HY-12304
-
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Histone Demethylase
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Cancer
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IOX1, 5-Carboxy-8-hydroxyquinoline, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .
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- HY-113071A
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- HY-Y1147
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Maleic acid diethyl ester
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|
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Diethyl maleate is a maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells .
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- HY-P3150
-
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Ser/Thr Protease
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Others
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Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations .
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- HY-113071R
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MVA (Standard)
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Endogenous Metabolite
|
Cardiovascular Disease
Neurological Disease
Metabolic Disease
|
Mevalonic acid (Standard) is the analytical standard of Mevalonic acid. This product is intended for research and analytical applications. Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .
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- HY-16658B
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Z-VAD-FMK
Maximum Cited Publications
297 Publications Verification
Z-VAD(OH)-FMK
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Caspase
Apoptosis
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Cancer
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Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM .
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- HY-P1933A
-
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CDK
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Cancer
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[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) .
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- HY-P2879
-
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Endogenous Metabolite
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Metabolic Disease
|
Cholesterol esterase, Pseudomonas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption .
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- HY-D1372
-
|
Fluorescent Dye
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Others
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Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λex=555 nm, λem=570 nm) .
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- HY-P1651
-
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TRP Channel
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Cancer
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SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity .
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- HY-P1651A
-
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TRP Channel
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Cancer
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SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 TFA has anticancer activity .
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- HY-D1372A
-
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Fluorescent Dye
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Others
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Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λex=555 nm, λem=570 nm) .
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- HY-16658
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Z-Val-Ala-Asp(OMe)-FMK
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Caspase
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Cancer
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Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .
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- HY-U00278
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(3β,20β)-3-(3-carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid
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Others
|
Inflammation/Immunology
|
Deloxolone has the potential for inflammatory, ischemic and proliferative diseases treatment.
|
-
- HY-P4086
-
|
RABV
|
Infection
|
Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is positively charged and able to bind negatively charged nucleic acids via charge interaction .
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- HY-Y0007
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L-Alanine, N-carboxy-, N-benzyl ester (6CI,7CI); (S)-2-(Benzyloxycarbonylamino)propanoic acid
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Amino Acid Derivatives
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Others
|
N-[(Benzyloxy)carbonyl]-L-alanine is an alanine derivative .
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- HY-P5272
-
|
Bacterial
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Inflammation/Immunology
|
Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
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- HY-N7833
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Heneicosapentaenoic acid
|
Biochemical Assay Reagents
|
Others
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Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.
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Cat. No. |
Product Name |
Type |
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- HY-D1094
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SNARF 1
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Fluorescent Dyes/Probes
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Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement of intracellular pH .
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- HY-D0114
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- HY-D2183
-
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Fluorescent Dyes/Probes
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6-Carboxy-JF5252 is a fluorophore. 6-Carboxy-JF5252 can be used as probes, dyes, tags. 6-Carboxy-JF5252 can be used for the research of super-resolution imaging .
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- HY-D1093
-
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Fluorescent Dyes/Probes
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Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
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- HY-D1972
-
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Fluorescent Dyes/Probes
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ATTO 610 Carboxy is a carboxyl derivative of ATTO 610 with maximum excitation/emission wavelengths: 616/633 nm.
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- HY-D1975
-
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Fluorescent Dyes/Probes
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ATTO 725 Carboxy is a carboxyl derivative of ATTO 725, the maximum excitation/emission wavelength is: 728/751 nm.
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- HY-D1980
-
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Fluorescent Dyes/Probes
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ATTO 620 Carboxy is a carboxyl derivative of ATTO 620, the maximum excitation/emission wavelength is: 620/642 nm.
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- HY-D2045
-
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Fluorescent Dyes/Probes
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ATTO 532 carboxy is a carboxyl derivative of ATTO 532, the maximum excitation/emission wavelength is: 532/552 nm.
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-
- HY-D2057
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Fluorescent Dyes/Probes
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ATTO 700 carboxy is a carboxyl derivative of ATTO 700 with maximum excitation/emission wavelengths: 700/716 nm.
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- HY-D2072
-
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Fluorescent Dyes/Probes
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ATTO 680 carboxy is a carboxyl derivative of ATTO 680, the maximum excitation/emission wavelength is: 681/698 nm.
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- HY-D2018
-
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Fluorescent Dyes/Probes
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ATTO 550 carboxy is a carboxyl derivative of ATTO 550 with maximum excitation/emission wavelengths: 554/576 nm.
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- HY-D2061
-
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Fluorescent Dyes/Probes
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ATTO 740 carboxy is a carboxyl derivative of ATTO 740, the maximum excitation/emission wavelength is: 743/763 nm.
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- HY-D1086
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6-ROX, SE
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Fluorescent Dyes/Probes
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6-Carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) is a fluorescent dye for oligonucleotide labeling and automated DNA sequencing .
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- HY-D0784
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5-ROX
1 Publications Verification
5-carboxy-X-rhodamine
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Oligonucleotide Labeling
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5-ROX (5-Carboxy-X-rhodamine), a rhodamine dye, exhibits strong fluorescence property in aqueous buffer with the λexit of 580 nm (ε=3.6×10 4 M -1 cm -1), and λemit of 604 nm (=0.94) .
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- HY-D1774
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-
- HY-D0053
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6-carboxy-X-rhodamine
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Oligonucleotide Labeling
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6-ROX, a fluorescent marker of oligonucleotides, acts as a receptor coupled to 5-FAM and as a donor in FRET imaging. Excitation wavelength: 568nm. Emission wavelength: 568nm.
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- HY-D0043
-
5(6)-carboxy-X-rhodamine
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Oligonucleotide Labeling
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5(6)-ROX is a nucleic acid fluorescent label which can be used as a reference dye for real-time polymerase chain reaction.
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- HY-D1372
-
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Fluorescent Dyes/Probes
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Cyanine3 amine hydrochloride, an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine hydrochloride has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λex=555 nm, λem=570 nm) .
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- HY-D1372A
-
|
Fluorescent Dyes/Probes
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Cyanine3 amine (TFA), an analog of Cyanine3 amine, is a potent green fluorescent dye. Cyanine3 amine (TFA) has the primary amine group and is covalently coupled with reactive groups such as NHS esters, carboxy groups (after carbodiimide activation), and epoxides. (λex=555 nm, λem=570 nm) .
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Cat. No. |
Product Name |
Type |
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- HY-150220
-
|
Drug Delivery
|
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can be used for the synthesis of phospholipid vesicle and improve the encapsulation efficiency of proteins .
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-
- HY-W751932
-
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Biochemical Assay Reagents
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Carboxy-EG6-undecanethiol is an alkanethiol that suitable for self-assembly a gold thin-film substrate. Carboxy-EG6-undecanethiol can selectively capture HbA1c in sample by covalent coupling of 3-aminophenyl boronic acid (3-APBA) .
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- HY-157918
-
20-(16-Mercaptohexadecanyloxy)-3,6,9,12,15,18-hexaoxaeicosanoic acid
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Biochemical Assay Reagents
|
Carboxy-EG6-hexadecanethiol is a biochemical assay reagent and can be used for chemical synthesis .
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-
- HY-N7833
-
Heneicosapentaenoic acid
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Biochemical Assay Reagents
|
Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.
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Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1199
-
|
Peptides
|
Others
|
pp60 c-src (521-533) (phosphorylated) is a peptide corresponding to the pp60c-src carboxy terminal regulatory domain, phosphorylated at Tyr527 .
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-
- HY-148218
-
|
Peptides
|
Endocrinology
|
N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine has the function of interfering with PAICS protein, which can effectively reduce SAICAR and SAICAr accumulation。
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- HY-P5954
-
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Peptides
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Others
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PLTX-II is a calcium channel blocker. PLTX-II has a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus .
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- HY-P1933
-
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Peptides
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Cancer
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[pSer2, pSer5, pSer7]-CTD, a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) .
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- HY-P1933A
-
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CDK
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Cancer
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[pSer2, pSer5, pSer7]-CTD (TFA), a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) .
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- HY-P1507
-
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Peptides
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Cardiovascular Disease
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Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). Fibrinogen Binding Inhibitor Peptide is a specific binding site of the ligand for activated glycoprotein (GP) IIb/IIIa.
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- HY-P1651
-
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TRP Channel
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Cancer
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SOR-C13, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 has anticancer activity .
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- HY-P1651A
-
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TRP Channel
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Cancer
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SOR-C13 TFA, a carboxy-terminal truncated peptide, is a high-affinity TRPV6 antagonist with an IC50 value of 14 nM. TRPV6 is a non-voltage gated calcium channel that is associated with malignancy and poor prognosis in breast cancer. SOR-C13 TFA has anticancer activity .
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- HY-P0306
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Heparin Binding Peptide
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Peptides
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Cardiovascular Disease
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Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells .
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- HY-P0306A
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Heparin Binding Peptide TFA
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Peptides
|
Cardiovascular Disease
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Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells .
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- HY-P4086
-
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RABV
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Infection
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Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R), a chimeric peptide consisting of 29 amino acids, is synthesized by adding nona-arginine motif to the carboxy terminus of RVG (rabies virus glycoprotein). Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R) is positively charged and able to bind negatively charged nucleic acids via charge interaction .
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-
- HY-P3727
-
|
Peptides
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Inflammation/Immunology
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Lys-Pro-Pro-Thr-Pro-Pro-Pro-Glu-Pro-Glu-Thr is a undecapeptide, corresponding to the carboxy terminus of simian virus 40 large T antigen. Lys-Pro-Pro-Thr-Pro-Pro-Pro-Glu-Pro-Glu-Thr can be targeted by antibodies secreted from three mouse hybridomas, designated KT1, KT3, and KT4, produced antibodies that immunoprecipitated large T antigen .
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- HY-Y0007
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L-Alanine, N-carboxy-, N-benzyl ester (6CI,7CI); (S)-2-(Benzyloxycarbonylamino)propanoic acid
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Amino Acid Derivatives
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Others
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N-[(Benzyloxy)carbonyl]-L-alanine is an alanine derivative .
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-
- HY-P5272
-
|
Bacterial
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Inflammation/Immunology
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Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
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Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
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Product Name |
Species |
Source |
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Tag |
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Accession |
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Gene ID |
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* This product has been "discontinued".
Optimized version of product available:
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Cat. No. |
Product Name |
Chemical Structure |
-
- HY-17502S1
-
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Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].
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-
- HY-17502S
-
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Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
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-
- HY-119695AS
-
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Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
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-
- HY-132636S
-
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(Rac)-5-Carboxy Tolterodine-d14 is the deuterium labeled (Rac)-5-Carboxy Tolterodine[1].
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-
- HY-132617S
-
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Carboxy Gliclazide-d4 is the deuterium labeled Carboxy Gliclazide[1].
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-
-
- HY-142842S
-
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Carboxy primaquine-d4 is the deuterium labeled Carboxy primaquine[1].
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-
-
- HY-133675S
-
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Mono(5-carboxy-2-ethylpentyl) phthalate-d4 (MECPP-d4) is a deuterium labeled Mono(5-carboxy-2-ethylpentyl) phthalate (HY-133675). Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
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-
- HY-132834S
-
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5-Carboxy-N-phenyl-2-1H-pyridone-d5 is the deuterium labeled 5-Carboxy-N-phenyl-2-1H-pyridone[1].
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Cat. No. |
Product Name |
Application |
Reactivity |
-
- HY-P81243
-
Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin; coagulation factor II (thrombin); Coagulation factor II; DCP; Factor II; Prepro coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain.
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WB=1:500-2000; ELISA=1:5000-10000; IHC-P=1:100-500; IHC-F=1:100-500; Flow-Cyt=1ug/test; IF=1:100-500
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Human, Mouse, Rat |
-
- HY-P81084
-
Angiotensin Converting Enzyme 1; ACE; ACE-T; Angiotensin-converting enzyme isoform 1precursor; Dipeptidyl carboxy peptidase 1; Kininase II; ACE-1; testis-specific isoform precursor. ACE 1; ACE T; ACE1; Angiotensin converting enzyme somatic isoform; Angiotensin converting enzyme testis specific isoform; Angiotensin I converting enzyme; Angiotensin I converting enzyme 1; Angiotensin I converting enzyme peptidyl dipeptidase A 1; carboxycathepsin; CD 143; CD143; CD143 antigen; DCP 1; DCP; DCP1; Dipeptidyl carboxypeptidase 1; MVCD3; Peptidase P; Peptidyl dipeptidase A; Testicular ECA; ACE_HUMAN.
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WB; ELISA; IHC-P; IHC-F; ICC; IF
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Human, Mouse, Rat(predicted: Dog, Pig, Cow, Sheep) |
ACE Antibody is an unconjugated, approximately 147 kDa, rabbit-derived, anti-ACE polyclonal antibody. ACE Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, sheep background without labeling.
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