1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. 8α,9α-Epoxycoleon-U-quinone

8α,9α-Epoxycoleon-U-quinone 

Cat. No.: HY-N10564
Handling Instructions

8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX.

For research use only. We do not sell to patients.

8α,9α-Epoxycoleon-U-quinone Chemical Structure

8α,9α-Epoxycoleon-U-quinone Chemical Structure

CAS No. : 93800-59-0

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Description

8α,9α-Epoxycoleon-U-quinone (compound 3) is a p-glycoprotein (P-gp) regulator that is selective for cancer cells (SI=2.0). 8α,9α-Epoxycoleon-U-quinone effectively inhibits P-gp activity in NCI-H460/R cells. 8α,9α-Epoxycoleon-U-quinone also reverses the resistance of cancer cells to Doxorubicin (DOX) (HY-15142A) and enhances the anticancer effect of DOX[1].

In Vitro

8α,9α-Epoxycoleon-U-quinone (2, 5, 10, 20, 50 μM; 72 h) selective towards cancer cell lines, with a selectivity index of 2.0[1].
8α,9α-Epoxycoleon-U-quinone (10 μM; 72 h) is able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells[1].
8α,9α-Epoxycoleon-U-quinone (1, 2, 5 μM; 72 h) reverses the resistance of cancer cells to DOX and increase anti-cancer efficacy of DOX[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NCI-H460, NCI-H460/R, MRC-5 cells
Concentration: 2, 5, 10, 20, 50 μM
Incubation Time: 72 h
Result: Showed inhibition of cancer cell viability (IC50≈20 μM) with a selectivity index of 2.0.

Cell Viability Assay[1]

Cell Line: NCI-H460/R cells
Concentration: 10 μM
Incubation Time: 72 h
Result: Decreased the Rho123 accumulation in NCI-H460/R cells, and no influence on the ABCB1 expression.

Cell Viability Assay[1]

Cell Line: NCI-H460/R cells
Concentration: 1, 2, 5 μM (combine with Doxorubicin (DOX))
Incubation Time: 72 h (pre-treat)
Result: Promoted sensitization of NCI-H4l60/R cells to DOX with relative reversal indexes of 1.976 and 4.696 for concentration of 1 and 2 μM, respectively.
Molecular Weight

360.40

Formula

C20H24O6

CAS No.
SMILES

O=C([[email protected]@]1(O[[email protected]@]213)C(C(O)=C4[[email protected]@]2(CCCC(C)4C)C)=O)C(C(C)C)=C(O)C3=O

Structure Classification
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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8α,9α-Epoxycoleon-U-quinone
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