1. GPCR/G Protein
  2. Cannabinoid Receptor

AM1241 

Cat. No.: HY-18640 Purity: >99.0%
Handling Instructions

AM1241 is a potent, typical and selective CB2 receptor agonist, with a Ki of 3.4 nM in a mouse spleen, and the Ki for CB1 receptor in rat brain is 280 nM, 82-fold selectivity for the CB2 receptor in rodent tissue. AM1241 relieves migraine, stroke, and neuropathic pain,also has a potent effect on Parkinson's disease. AM1241 prevents oxidative damage and activates STAT3 through the phosphorylation of Akt and Erk1/2.

For research use only. We do not sell to patients.

AM1241 Chemical Structure

AM1241 Chemical Structure

CAS No. : 444912-48-5

Size Price Stock Quantity
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 Get quote
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AM1241 is a potent, typical[2] and selective CB2 receptor agonist, with a Ki of 3.4 nM in a mouse spleen, and the Ki for CB1 receptor in rat brain is 280 nM, 82-fold selectivity for the CB2 receptor in rodent tissue[1]. AM1241 relieves migraine, stroke, and neuropathic pain,also has a potent effect on Parkinson's disease[2]. AM1241 prevents oxidative damage and activates STAT3 through the phosphorylation of Akt and Erk1/2[3].

IC50 & Target

Ki: 3.4 nM (Mouse spleen CB2 receptor), 280 nM (Rat brain CB1 receptor)[1]

In Vitro

AM1241 is a potent and selective CB2 receptor agonist, with a Ki of 3.4 nM in a mouse spleen, and the Ki for CB1 receptor in rat brain is 280 nM, 82-fold selectivity for the CB2 receptor in rodent tissue[1].
AM1241 decreases oxidative stress levels, enhances the production of paracrine growth factors, decreases TGF-β1 and PDGF levels, activates Stat3 via the phosphorylation of Akt and Erk1/2[3].

In Vivo

AM1241 (0.1-3 mg/kg, i.p.) dose-dependently inhibits sensory hypersensitivity in rats. AM1241 inhibits tactile hypersensitivity and thermal hypersensitivity at 1 mg/kg and 3 mg/kg, respectively, in mice lacking the CB1 receptor[1].
AM1241 (0.75, 1.5, 3, 6, 12 mg/kg, i.p.) alleviates MPTP-induced Parkinson's disease and promotes the regeneration of dopaminergic (DA) neurons in PD mice[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9868 mL 9.9338 mL 19.8677 mL
5 mM 0.3974 mL 1.9868 mL 3.9735 mL
10 mM 0.1987 mL 0.9934 mL 1.9868 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

503.33

Formula

C₂₂H₂₂IN₃O₃

CAS No.

444912-48-5

SMILES

O=C(C1=CC([N+]([O-])=O)=CC=C1I)C2=CN(CC3N(C)CCCC3)C4=C2C=CC=C4

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AM1241
Cat. No.:
HY-18640
Quantity:

AM1241

Cat. No.: HY-18640