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ARL67156 trisodium salt 

Cat. No.: HY-103265 Purity: >98.0%
Handling Instructions

ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively.

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ARL67156 trisodium salt Chemical Structure

ARL67156 trisodium salt Chemical Structure

CAS No. : 1021868-83-6

Size Price Stock Quantity
10 mM * 1 mL in Water USD 607 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1].

IC50 & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)[1]

In Vitro

ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes[1].

Molecular Weight

788.08

Formula

C₁₅H₂₄Br₂N₅Na₃O₁₂P₃

CAS No.

1021868-83-6

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(C(Br)(Br)P(O)(O)=O)(O)=O)(O)=O)[[email protected]]1O)N2C3=NC=NC(N(CC)CC)=C3N=C2.[3Na]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (31.72 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2689 mL 6.3445 mL 12.6891 mL
5 mM 0.2538 mL 1.2689 mL 2.5378 mL
10 mM 0.1269 mL 0.6345 mL 1.2689 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Product Name:
ARL67156 trisodium salt
Cat. No.:
HY-103265
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