1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. ARL67156 trisodium salt

ARL67156 trisodium salt 

Cat. No.: HY-103265 Purity: >99.0%
Handling Instructions

ARL67156 trisodium salt est un inhibiteur de l'ecto-ATPase. ARL67156 trisodium salt est un inhibiteur compétitif faible de NTPDase1 (CD39), NTPDase3 et NPP1, avec des Ki de 11, 18 et 12 μM, respectivement. ARL67156 trisodium salt empêche le développement in vivo de la maladie de la valve aortique calcifiante.

ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 trisodium salt is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 trisodium salt prevents in vivo the development of calcific aortic valve disease.

For research use only. We do not sell to patients.

ARL67156 trisodium salt Chemical Structure

ARL67156 trisodium salt Chemical Structure

CAS No. : 1021868-83-6

Size Price Stock Quantity
10 mM * 1  mL in Water USD 607 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 trisodium salt is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt prevents in vivo the development of calcific aortic valve disease[2].

IC50 & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)[1]

In Vitro

ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes[1].

Molecular Weight

785.05

Formula

C₁₅H₂₁Br₂N₅Na₃O₁₂P₃

CAS No.

1021868-83-6

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(C(Br)(Br)P(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[[email protected]]1O)N2C3=NC=NC(N(CC)CC)=C3N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (31.85 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2738 mL 6.3690 mL 12.7380 mL
5 mM 0.2548 mL 1.2738 mL 2.5476 mL
10 mM 0.1274 mL 0.6369 mL 1.2738 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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Keywords:

ARL67156 trisodiumPhosphataseInhibitorinhibitorinhibit

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ARL67156 trisodium salt
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