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ARL67156 trisodium salt 

Cat. No.: HY-103265 Purity: >98.0%
Handling Instructions

ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively.

For research use only. We do not sell to patients.

ARL67156 trisodium salt Chemical Structure

ARL67156 trisodium salt Chemical Structure

CAS No. : 1021868-83-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 607 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1].

IC50 & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)[1]

In Vitro

ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes[1].

References
Molecular Weight

788.08

Formula

C₁₅H₂₄Br₂N₅Na₃O₁₂P₃

CAS No.

1021868-83-6

SMILES

O[[email protected]]1[[email protected]@H](O[[email protected]](COP(OP(C(Br)(Br)P(O)(O)=O)(O)=O)(O)=O)[[email protected]]1O)N2C3=NC=NC(N(CC)CC)=C3N=C2.[3Na]

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
ARL67156 trisodium salt
Cat. No.:
HY-103265
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ARL67156 trisodium salt

Cat. No.: HY-103265