1. Neuronal Signaling
  2. Beta-secretase
  3. AZD3839 free base

AZD3839 free base 

製品番号: HY-13438 純度: 99.99%
取扱説明書

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.

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AZD3839 free base 構造式

AZD3839 free base 構造式

CAS 番号 : 1227163-84-9

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 172 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 156 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 240 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 480 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 840 在庫あり
Estimated Time of Arrival: December 31
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. target: BACE1, β-secretase enzyme [1] IC50: 23.6 uM [1] AZD3839 dissolved in 0.33% dimethylsulfoxide In vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself. [1] In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3. Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2). [1]AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. [2]

臨床実験
分子量

431.41

分子式

C₂₄H₁₆F₃N₅

CAS 番号

1227163-84-9

SMILES

FC1=C2C([[email protected]](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (289.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3180 mL 11.5899 mL 23.1798 mL
5 mM 0.4636 mL 2.3180 mL 4.6360 mL
10 mM 0.2318 mL 1.1590 mL 2.3180 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AZD3839AZD 3839AZD-3839Beta-secretaseBACEβ-SecretaseInhibitorinhibitorinhibit

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Inquiry Information

製品名:
AZD3839 free base
製品番号:
HY-13438
数量:
MCE 日本正規代理店: