AZD3839 free base

Name: AZD3839 free base
Brand: MedChemExpress
SKU: HY-13438
Rating: 4.5 (1 reviews)

製品番号: HY-13438 純度: 99.98%: FAQs
Data Sheet SDS COA 取扱説明書

Molarity Calculator

AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor (K_i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

AZD3839 free base 構造式

CAS 番号 : 1227163-84-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 157	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 157	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	USD 143	在庫あり	Estimated Time of Arrival: December 31
10 mg	USD 220	在庫あり	Estimated Time of Arrival: December 31
25 mg	USD 440	在庫あり	Estimated Time of Arrival: December 31
50 mg	USD 770	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of AZD3839 free base:

(Rac)-AZD3839 お問い合わせ

顧客検証

•Neuron. 2023 Apr 4;S0896-6273(23)00220-9. [Abstract]

Beta-secretase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

BACE1 BACE2

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

臨床実験

分子量

431.41

分子式

C₂₄H₁₆F₃N₅

CAS 番号

1227163-84-9

Appearance

Solid

Color

White to off-white

SMILES

FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (289.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3180 mL	11.5899 mL	23.1798 mL
5 mM	0.4636 mL	2.3180 mL	4.6360 mL
10 mM	0.2318 mL	1.1590 mL	2.3180 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.82 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.98%

Select Batch:

データシート (279 KB) SDS (0 KB)

COA (255 KB) LCMS (266 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Sparve E et al. Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78. [Content Brief]

[2]. Jeppsson F et al. Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3180 mL	11.5899 mL	23.1798 mL	57.9495 mL
	5 mM	0.4636 mL	2.3180 mL	4.6360 mL	11.5899 mL
	10 mM	0.2318 mL	1.1590 mL	2.3180 mL	5.7950 mL
	15 mM	0.1545 mL	0.7727 mL	1.5453 mL	3.8633 mL
	20 mM	0.1159 mL	0.5795 mL	1.1590 mL	2.8975 mL
	25 mM	0.0927 mL	0.4636 mL	0.9272 mL	2.3180 mL
	30 mM	0.0773 mL	0.3863 mL	0.7727 mL	1.9317 mL
	40 mM	0.0579 mL	0.2897 mL	0.5795 mL	1.4487 mL
	50 mM	0.0464 mL	0.2318 mL	0.4636 mL	1.1590 mL
	60 mM	0.0386 mL	0.1932 mL	0.3863 mL	0.9658 mL
	80 mM	0.0290 mL	0.1449 mL	0.2897 mL	0.7244 mL
	100 mM	0.0232 mL	0.1159 mL	0.2318 mL	0.5795 mL