1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Alloepipregnanolone 

Cat. No.: HY-113307
Handling Instructions

Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol.

For research use only. We do not sell to patients.

Alloepipregnanolone Chemical Structure

Alloepipregnanolone Chemical Structure

CAS No. : 516-55-2

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol.

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1398 mL 15.6991 mL 31.3982 mL
5 mM 0.6280 mL 3.1398 mL 6.2796 mL
10 mM 0.3140 mL 1.5699 mL 3.1398 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Male Swiss mice are pretreated with Alloepipregnanolone (isopregnanolone: 0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals tested using the plus-maze apparatus. The first experiment defines the doses of ethanol that does or does not induce rapid tolerance to the anxiolytic effect of ethanol. In the second, the influence of pretreatment of mice with Alloepipregnanolone (0.05, 0.10 or 0.20 mg/kg) on rapid tolerance to ethanol (1.5 g/kg) is studied[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

318.49

Formula

C₂₁H₃₄O₂

CAS No.

516-55-2

SMILES

CC([[email protected]]1CC[[email protected]@]2([H])[[email protected]]3([H])CC[[email protected]@]4([H])C[[email protected]@H](O)CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Alloepipregnanolone
Cat. No.:
HY-113307
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Alloepipregnanolone

Cat. No.: HY-113307