1. Metabolic Enzyme/Protease
  2. Proteasome
  3. BDA-410

BDA-410 

Cat. No.: HY-111808
Handling Instructions

BDA-410 is a selective calpain-1 inhibitor with a Ki value of 130 nM (calpain-2 = 630 nM). BDA-410 inhibits recombinant falcipain-2B with an IC50 of 628 nM and exhibits anti-malarial effects.

For research use only. We do not sell to patients.

BDA-410 Chemical Structure

BDA-410 Chemical Structure

CAS No. : 147660-55-7

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Description

BDA-410 is a selective calpain-1 inhibitor with a Ki value of 130 nM (calpain-2 = 630 nM). BDA-410 inhibits recombinant falcipain-2B with an IC50 of 628 nM and exhibits anti-malarial effects[1].

IC50 & Target

Ki: 130 nM (Calpain-1), 630 nM (Calpain-2)[1]
IC50: 628 nM (Recombinant falcipain-2B)[1]

In Vitro

BDA-410 inhibits malaria parasite growth in vitro with an IC50 value of 173 nM[1].

In Vivo

BDA-410 (25 mg/kg; i.p. injection for three times per day; 4 days) rapidly clears parasitemia in vivo resulting in ~72% inhibition with no obvious detrimental effects due to inhibitor treatment in infected mice. All BDA-410 treated mice survive for longer[1].

Animal Model: C57BL/6 mice (4-6 weeks of age, 20-22g of weight)[1]
Dosage: 25 mg/kg
Administration: Given i.p. injection; three times per day for 4 days
Result: Rapidly cleared parasitemia in vivo resulting in ~72% inhibition with no obvious detrimental effects due to inhibitor treatment in infected mice.BDA-410 treated mice survived until around day 23 compared with control group; and two of the eight BDA-410 treated mice survived until day 60.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

484.61

Formula

C₂₆H₃₂N₂O₅S

CAS No.

147660-55-7

SMILES

CC(C)C[[email protected]](NS(=O)(C1=CC=CC=C1)=O)C(N[[email protected]]([[email protected]@H](O)C2=C(C3=CC=CC=C3)C2=O)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BDA-410
Cat. No.:
HY-111808
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BDA-410

Cat. No.: HY-111808