1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. JWG-071

JWG-071 

Cat. No.: HY-108886 Purity: 98.55%
Handling Instructions

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology.

For research use only. We do not sell to patients.

JWG-071 Chemical Structure

JWG-071 Chemical Structure

CAS No. : 2250323-50-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 954 In-stock
Estimated Time of Arrival: December 31
5 mg USD 708 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].

IC50 & Target

ERK5

88 nM (IC50)

In Vitro

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].

Molecular Weight

612.76

Formula

C₃₄H₄₄N₈O₃

CAS No.

2250323-50-1

SMILES

COC1=CC(C(N2CCC(N3CCN(C)CC3)CC2)=O)=CC=C1NC4=NC=C(N(C)C5=O)C(N(C6=CC=CC=C65)C(C)CC)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

JWG-071JWG071JWG 071ERKExtracellular signal regulated kinasesselectivechemicalprobebromodomainLRRK2BRD4Inhibitorinhibitorinhibit

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JWG-071
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HY-108886
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